Balkan Journal of Medical Genetics

POLYMORPHISM OF THE ADRB2 rs1042713 GENE IS NOT ASSOCIATED WITH SPONTANEOUS PRETERM BIRTH: ANALYSES IN A SLOVENIAN SAMPLE AND META ANALYSIS
Peterlin A1, Maver A1, Jan Z2, Lovrecic L1, Tul N2, Peterlin B1
*Corresponding Author: Professor Borut Peterlin, Clinical Institute of Medical Genetics, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia. Tel/Fax: +386-1-5401-137. E -mail: borut.peterlin@guest.arnes.si
page: 35

RESULTS

Case-Control Association Study in the Slovenian Population. Cases and controls did not differ in any demographic characteristic or recognized risk factor for SPTB. The history of a previous SPTB was more frequent in the SPTB group (12.4%) in comparison to controls (4.3%), however, the difference did not reach statistical significance (Table 1). Genotype frequencies of investigated polymorphisms were in accordance with those predicted by the Hardy- Weinberg equilibrium in the group of patients and in the control group. Genotype and allelic distribution of the ADRB2 polymorphism of the 98 SPTB patients and 135 controls are shown in Table 2. The ADRB2 rs1042713 genotypes were not found to be associated with the risk of SPTB in the Slovene population under any of the investigated models, dominant, recessive, and codominant (Table 3). Meta Analyses. The initial keyword search identified 17 articles (Figure 1). Four previously published casecontrol studies were included after a review together with added results of our case-control study based on characteristics summarized in Table 4. Therefore, five studies met inclusion criteria with a total of 404 SPTB cases and 878 term controls. Association of Genotype and Phenotype. Cochrane’s Q test and I2 test showed that there was no evidence of heterogeneity across all studies under the recessive genetic model, while moderate heterogeneity was present under the dominant genetic model. We found that there was no significant association of ADRB2 rs1042713 polymorphism with SPTB under the dominant (AA+GA vs. GG) or recessive (GG vs. AA+GA) genetic models (Figure 2). We analyzed the asymmetry of the funnel plot with Egger’s test and found no evidence for publication bias.

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