MOLECULAR AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF COMPLETE HYDATIDIFORM MOLES
Kubelka-Sabit KB1,*, Prodanova I2, Jasar D1, Bozinovski G3, Filipovski V1, Drakulevski S1, Plaseska-Karanfilska D3
*Corresponding Author: Dr. Katerina B. Kubelka-Sabit, Clinical Hospital Acibadem Sistina, Skupi 5a, 1000 Skopje, Republic of Macedonia. Tel: +389-70-365-338. Fax: +389-23-099-599. E-mail: catkubelka@ yahoo.co.uk; katerina.kubelka@acibademsistina.mk
page: 27

REFERENCES

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Diagnostic value of P63 in differentiating normal gestation from molar pregnancy. J Res Med Sci. 2013; 18(6): 462-466. 7. Carey L, Nash BM, Wright DC. Molecular genetic studies of complete hydatidiform moles. Transl Pediatr. 2015; 4(2): 181-188. 8. Kipp BR, Ketterling RP, Oberg TN, Cousin MA, Plagge AM, Wiktor AE, et al. Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conception. Am J Clin Pathol. 2010; 133(2): 196-204. 9. Landolsi H, Missaoui N, Yacoubi MT, Trabelsi A, Rammeh-Rommani S, Hidar S, et al. Assessment of the role of histopathology and DNA image analysis in the diagnosis of molar and non-molar abortion: a study of 89 cases in the center of Tunisia. Pathol Res Pract. 2009; 205(11): 789-796. 10. Sarmadi S, Izadi-Mood N, Abbasi A, Sanii S. p57KIP2 immunohistochemical expression: A useful diagnostic tool in discrimination between complete hydatidiform mole and its mimics. Arch Gynecol Obstet. 2011; 283(4): 743-748. 11. Niemann I, Petersen LK, Hansen ES, Sunde L. Differences in current clinical features of diploid and triploid hydatidiform mole. BJOG. 2007; 114(10): 1273-1277. 12. Fukunaga M. Immunohistochemical characterization of p57Kip2 expression in tetraploid hydropic placentas. Arch Pathol Lab Med. 2004; 28(8): 897-900. 13. Bewtra C, Frankforter S, Marcus JN. Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles. Int J Gynecol Pathol. 1997; 16(3): 239-244. 14. Candelier JJ. [Complete hydatidiform mole]. Med Sci (Paris). 2015; 31(10): 861-868. 15. Chen, CP, Ko TM, Chen CY, Wang TY, Chern SR, Kuo YL, et al. First-trimester molecular diagnosis of complete hydatidiform mole associated with dizygotic twin pregnancy conceived by intrauterine insemination. Taiwan J Obstet Gynecol. 2014; 53(4): 572-578. 16. Niemann I, Sunde L, Petersen LK. Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus. Am J Obstet Gynecol. 2007; 197(1): 45.e1-e5. 17. Paul M, Goodman S, Felix J, Lewis R, Hawkins M, Drey E. Early molar pregnancy: Experience in a large abortion service. Contraception. 2010; 81(2): 150-156. 18. Banet N, DeScipio C, Murphy K, Beierl K, Adams E, Vang R, et al. Characteristics of hydatidiform moles: Analysis of a prospective series with p57 immunohistochemical and molecular genotyping. Mod Pathol. 2014; 27(2): 238-254. 19. Sasaki S, Sasaki Y, Kunimura T, Sekozawa A, Kojima Y, Iino K. Clinical Usefulness of immunohistochemical staining of p57 kip2 for the differential diagnosis of complete mole. Biomed Res Int. 2015; 2015: 905648. 20. Fisher RA, Hodges MD, Rees HC, Sebire NJ, Seckl MJ, Newlands ES, et al. The maternally transcribed gene p57(KIP2) (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles. Hum Mol Genet. 2002; 11(26): 3267-3272. 21. Ramalho LN, Maggiori MS, Ribeiro-Silva A, Peres LC. P63 expression in hydropic abortion and gestational trophoblastic diseases. Placenta. 2006; 27(6-7): 740-743. 22. Hemida R, van Doorn H, Fisher R. A novel genetic mutation in a patient with recurrent biparental complete hydatidiform mole: A brief report. Int J Gynecol Cancer. 2016; 26(7): 1351-1353. 23. Parry DA, Logan CV, Hayward BE, Shires M, Landolsi H, Diggle C, et al. Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. Am J Hum Genet. 2011; 89(3): 451-458. 24. Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R, et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet. 2006; 38(3): 300-302. 25. Hayward BE, De Vos M, Talati N, Abdollahi MR, Taylor GR, Meyer E, et al. Genetic and epigenetic analysis of recurrent hydatidiform mole. Hum Mutat. 2009; 30(5): E629-E639. 26. Akoury E, Gupta N, Bagga R, Brown S, Dery C, Kabra M, et al. Live births in women with recurrent hyda-tidiform mole and two NLRP7 mutations. Reprod Biomed Online. 2015; 31(1): 120-124. 27. Reubinoff BE, Lewin A, Verner M, Safran A, Schenker JG, Abeliovich D. Intracytoplasmic sperm injection combined with preimplantation genetic diagnosis for the prevention of recurrent gestational trophoblastic disease. Hum Reprod. 1997; 12(4): 805-808. 28. Fisher RA, Khatoon R, Paradinas FJ, Roperts AP, Newlands ES. Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Hum Reprod. 2000; 15(3): 594-598. 29. Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA. Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod. 2015; 30(9): 2055-2063. 30. Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG. 2003; 110(1): 22-26. 31. Petts G, Fisher RA, Short D, Linday I, Seckl ML, Sebire NJ. Histopathological and immunohistochemical features of early hydatidiform mole in relation to subsequent development of persistent gestational trophoblastic disease. J Reprod Med. 2014; 59(5-6): 213-220.



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