POLYMORPHISMS OF α1-ANTITRYPSIN AND
INTERLEUKIN-6 GENES AND THE PROGRESSION
OF HEPATIC CIRRHOSIS IN PATIENTS WITH
A HEPATITIS C VIRUS INFECTION
Motawi T, Shaker OG, Hussein RM, Houssen M
*Corresponding Author: Rasha M. Hussein, Ph.D., Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University,
Salah Salem Street, 62511, Beni-Suef, Egypt. Tel: +20-12-0013-6515. Fax: +20-82-2317-958. E-mail: rasha.hussein@
pharm.bsu.edu.eg
page: 35
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CONCLUSIONS
We concluded that the inheritance of the deficient S
and Z variants of the A1AT gene but not IL-6 (–174 G/C)
mutation were associated with progressive liver diseases
and liver cirrhosis. However, the small sample size of the
current study did not allow us to extrapolate these results
in the Egyptian HCV-infected patients. Even though we
recommend screening the HCV-infected patients for the
existence of the A1AT and IL-6 gene mutations in order to
follow their future progression to liver cirrhosis.
Declaration of Interest. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
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