CYP2D6 ALLELE DISTRIBUTION IN MACEDONIANS, ALBANIANS AND ROMANIES IN THE REPUBLIC OF MACEDONIA
Kuzmanovska M, Dimishkovska M, Maleva Kostovska I, Noveski P, Sukarova Stefanovska E, Plaseska-Karanfilska D*
*Corresponding Author: Dijana Plaseska-Karanfilska, M.D., Ph.D., Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov,” Macedonian Academy of Sciences and Arts, Krste Misirkov 2, 1000 Skopje, Republic of Macedonia. Tel: +389-2-3235-410. Fax: +389-2-3115-434. E-mail: dijana@manu.edu.mk
page: 49

RESULTS

Table 2 summarizes the allele frequencies of the three groups. Of the fully functional alleles, the most frequent variant was the wild type allele *1 (in 36.5% of Macedonians, 33.0% of Romanies and 37.0% of Albanians), followed by allele *2 (in 25.5% of Macedonians, 21.5% of Romanies and 25.5% of Albanians). The decreased activity alleles were observed in 23.5% of the Romany population, in 14.0% of the Macedonian and in 11.5% of the Albanian. Four decreased activity alleles were detected, i.e.,*9, *10, *29 and *41, from which allele *41 stood out as the most frequent variant. The frequency of the allele *41 in the Romanies (23.0%) is higher in comparison with the Macedonians (11.0%) and Albanians (10.5%), and this difference is statistically significant (p =0.002 and p = 0.0012, respectively). The *9 allele was detected only in the Romany (0.5%) and the Albanian population (0.5%), whereas the *10 allele was present exclusively in the Macedonian and Albanian population with frequencies of 1.5 and 0.5%, respectively. The *29 allele was observed solely in the Macedonian ethnic group (1.5%). Non functional alleles were found in 30.0% of the Albanians, 21.5% of the Macedonians and 17.5% of the Romanies. The non functional *4 allele was found in 22.5% of the Albanians, 17.0% of the Macedonians and 15.0% of the Romanies. Alleles *3, *5 and *6 were present in 3.5, 2.5 and 1.5%, respectively, of the Albanians, in 2.0, 1.5 and 1.0%, respectively, of the Macedonians, and in 1.5, 0.5 and 0.5%, respectively, of the Romanies. Five duplications (four *1xN alleles and one *2xN allele) were identified in the Macedonian group. Only one duplication was found in each of the Albanian (*2xN) and Romany (*1xN) groups. Table 3 summarizes the CYP2D6 genotypes and corresponding phenotypes found in the three groups. The *1/*2 genotype was present in 20.0% of the Macedonian and in 17.0% of the Romany group. The*1/*4 genotype was present in 17.0% of the Albanian group. We yielded statistically significant results for the frequency of the genotypes *1/*41 and *2/*41, which were found in 12.0 and 17.0%, respectively, of the Romany and in 5.0% for each genotype in the Macedonians (p = 0.013 and p = 0.0357, respectively) (Table 3).



Number 22
VOL. 22, 2019 Accepted articles
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Accepted articles
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006