THE CHEK2 del5395 IS A FOUNDER MUTATION WITHOUT DIRECT EFFECTS FOR CANCER RISK IN THE LATVIAN POPULATION
Plonis J*, Kalniete D, Nakazawa-Miklasevica M, Irmejs A, Vjaters E, Gardovskis J, Miklasevics E
*Corresponding Author: Juris Plonis, M.D., Institute of Oncology, Riga Stradins University, Dzirciema 16, LV- 1007, Riga, Latvia. Tel: +371-2915-9476. Fax: +371-6706-9904. E-mail: juris.plonis@inbox.lv
page: 33

RESULTS

In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group with a frequency of 1.00% [OR = 1.32; 95% confidence interval (CI) 0.24-7.13; p = 0.73), whereas in cases of prostate cancer its frequency was the lowest 0.24% (OR = 0.31; 95% CI 0.06-3.7; p = 0.39) (Table 1). As far as the control groups are concerned, the healthy donors’ group was marked by the most frequent del5395 mutation (0.76%), whereas its frequency in the Chernobyl liquidators group and the geriatric group was 0.83% (OR = 1.09; 95% CI 0.20-5.90; p = 1.0) and 0.68% (OR = 0.89; 95% CI 0.13-5.28; p = 1.0), respectively (Table 1). For both the cancer and control groups OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00.



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