Balkan Journal of Medical Genetics

THE RELATIONSHIP BETWEEN TRANSCRIPT EXPRESSION LEVELS OF NUCLEAR ENCODED (TFAM, NRF1) AND MITOCHONDRIAL ENCODED (MT-CO1) GENES IN SINGLE HUMAN OOCYTES DURING OOCYTE MATURATION
Ghaffari Novin M, Allahveisi A, Noruzinia M, Farhadifar F, Yousefian E, Dehghani Fard A, Salimi M
*Corresponding Author: Dr. Azra Allahveisi, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Pasdaran Street, Sanandaj, Iran. Tel: +98-873-664-673. Fax: +98-873-364- 674. E-mail: allavaisie@gmail.com
page: 39

RESULTS

For the first time, the present study showed detailed temporal expression of mRNAs associated to mitochondria during human oocyte maturation. Results showed that the mean expression levelsof TFAM and NRF1were relatively low as well as the MT-CO1 genes in GV-stage oocytes. No significant difference was seen between the expression levels of all studied genes (p = 0.62) (Figure 1A). Significant differences were detected in the mean expression levels of TFAM and NRF1, and the MT-CO1 genes when the oocyte maturation began and transited to the MI stage (p = 0.03) (Figure 1B). At the MII stage, significant differences were reported between the expression levels of TFAM and NRF1, and the MT-CO1 (p = 0.002) genes (Figure 1C). Furthermore, significant differences were seen between the expression levels of NRF1 and TFAM, and the MT-CO1 genes at the MI and MII stages (Figure 2).

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