ROLE OF THE CYP1A2 GENE POLYMORPHISM ON EARLY AGEING FROM OCCUPATIONAL EXPOSURE
Eshkoor SA1,2,*, Ismail P1, Rahman SA2, Moin S2, Adon MY3
*Corresponding Author: Dr. Sima A. Eshkoor, Institute of Gerontology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Malaysia; Tel.: +60-129-797-812; Fax: +60-389-472-744; E-mail: simaataolahi@yahoo.com
page: 45

DISCUSSION

DNA damage can occur due to the effects of the CYP1A2 gene and environmental factors [12]. The subjects showed a shorter telomere length on the mutated genotype yet a higher MN frequency in both wild and mutated genotypes. Such effects suggest the possible influence of gene polymorphism on DNA damage mediation in the cells [13], which could be due to the increased enzyme activity as well as sensitivity of cells to genotoxic effects [12]. Despite the paradoxical reports, our result confirmed a correlation between the different genotypes and MN frequency [14]. Such correlation is probably due to more sensitivity of MN than the other biomarkers to express the effects of genotypes on genetic material damage from occupational exposure. Contrary to previous reports indicating DNA damage in the cells [5,6,15], no statistically significant influence was observed on comet tail length in our research either in wild or mutated genotypes. In the current study, age did not contribute to enhance the influence of the CYP1A2 gene presenting in higher MN, shorter telomere length and greater comet tail length in workers and controls, except greater comet tail length in the younger group of workers. Lack of age effects suggest a protection effect of gene against ageing. Apparently, the CYP1A2 gene prevents the modulation of DNA damage [16-18] by transcriptional activation and resistance to changes, which can be interfered with lifestyle factors [19,20], different genotypes and genes interactions [21]. Among all lifestyle factors, only ethnicity significantly affected MN frequency regardless of occupational exposure, which indicates the possible influence of gene polymorphism on the cell protection against genome damage [22]. Meanwhile, this research was a confirmation of the studies [23,24] indicating the association of DNA damage with working duration time. It seems that good interpretation of results depends on a suitable sample size in each group of various genotypes and age. However, the study was cross-sectional, therefore, finding effective and non effective factors were difficult. Another limitation of the study was the difficulty of determining and isolating the exact effects of gene polymorphisms. Despite the above limitations, this study can serve as a base to address the effects of these genotypes and surrounding risk factors on early ageing. Accordingly, CYP1A2 genotypes contributed to DNA damage from occupational exposure, hence, further investigations are needed to evaluate the exact effects of different genotypes on a subject’s premature aging.



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