ROLE OF THE CYP1A2 GENE POLYMORPHISM ON
EARLY AGEING FROM OCCUPATIONAL EXPOSURE Eshkoor SA1,2,*, Ismail P1, Rahman SA2, Moin S2, Adon MY3 *Corresponding Author: Dr. Sima A. Eshkoor, Institute of Gerontology, Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia (UPM), 43400, Malaysia; Tel.: +60-129-797-812; Fax: +60-389-472-744;
E-mail: simaataolahi@yahoo.com page: 45
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DISCUSSION
DNA damage can occur due to the effects of the
CYP1A2 gene and environmental factors [12]. The
subjects showed a shorter telomere length on the mutated
genotype yet a higher MN frequency in both
wild and mutated genotypes. Such effects suggest the
possible influence of gene polymorphism on DNA
damage mediation in the cells [13], which could be due
to the increased enzyme activity as well as sensitivity
of cells to genotoxic effects [12]. Despite the paradoxical
reports, our result confirmed a correlation between
the different genotypes and MN frequency [14]. Such
correlation is probably due to more sensitivity of MN
than the other biomarkers to express the effects of
genotypes on genetic material damage from occupational
exposure. Contrary to previous reports indicating
DNA damage in the cells [5,6,15], no statistically
significant influence was observed on comet tail length
in our research either in wild or mutated genotypes.
In the current study, age did not contribute to enhance
the influence of the CYP1A2 gene presenting in
higher MN, shorter telomere length and greater comet
tail length in workers and controls, except greater
comet tail length in the younger group of workers.
Lack of age effects suggest a protection effect of gene
against ageing. Apparently, the CYP1A2 gene prevents
the modulation of DNA damage [16-18] by transcriptional
activation and resistance to changes, which can
be interfered with lifestyle factors [19,20], different
genotypes and genes interactions [21].
Among all lifestyle factors, only ethnicity significantly
affected MN frequency regardless of occupational
exposure, which indicates the possible influence
of gene polymorphism on the cell protection against
genome damage [22]. Meanwhile, this research was
a confirmation of the studies [23,24] indicating the
association of DNA damage with working duration
time. It seems that good interpretation of results depends on a suitable sample size in each group of
various genotypes and age. However, the study was
cross-sectional, therefore, finding effective and non
effective factors were difficult. Another limitation
of the study was the difficulty of determining and
isolating the exact effects of gene polymorphisms.
Despite the above limitations, this study can serve as
a base to address the effects of these genotypes and
surrounding risk factors on early ageing. Accordingly,
CYP1A2 genotypes contributed to DNA damage from
occupational exposure, hence, further investigations
are needed to evaluate the exact effects of different
genotypes on a subject’s premature aging.
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