TWENTY-FOUR GENES ARE UPREGULATED
IN PATIENTS WITH HYPOSPADIAS
Karabulut R1, Turkyilmaz Z1, Sonmez K1, Kumas G2, Ergun SG2, Ergun MA2,*, Basaklar AC1
*Corresponding Author: Mehmet A. Ergun, M.D., Ph.D., Department of Medical Genetics, Gazi University
Faculty of Medicine, Besevler, Ankara, Turkey; Tel.: +90 312 2024637; Fax. +90 312 2024635; E-mail:
aliergun@gazi.edu.tr
page: 39
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REFERENCES
1. van der Zanden LF, van Rooij IA, Feitz WF, Vermeulen
SH, Kiemeney LA, Knowers NV, et al.
Genetics of hypospadias: are single-nucleotide
polymorphisms in SRD5A2, ESR1, ESR2, ATF3
really associated with the malformation? J Clin
Endocrinol Metab. 2010; 95(5): 2384-2390.
2. Putsch B, Albers N, Ludwig M. Genetic and
molecular aspects of hypospadias. Eur J Pediatr
Surg. 2004; 14(5): 297-302.
3. Paulozzi LJ. International trends in rates of hypo-
spadias and cryptorchidism. Environ Health
Perspect. 1999; 107(4): 297-302.
4. Liu B, Wang Z, Lin G, Agras K, Embers M,
Wil-lingham E, et al. Activating transcription
factor 3 is up-regulated in patients with hypospadias.
Pediatr Res. 2005; 58(6): 1280-1283.
5. Kalfa N, Philibert P, Baskin LS, Sultan C.
Hypo-spadias: interactions between environment
and genetics. Mol Cell Endocrinol. 2011;
335(2): 89-95.
6. Li M, Qiu L, Lin T, He D, Hua Y, Yuan X, et al.
c-Jun N-terminal kinase is upregulated in patients
with hypospadias. Urology. 2013; 81(1):
178-183.
7. Choudhry S, Deshpande A, Qiao L, Beckman
K, Sen S, Baskin LS. Genome-wide DNA methylation
profiling of CpG islands in hypospadias.
J Urol. 2012; 188(4 Suppl): 1450-1455.
8. Willingham E, Baskin LS. Candidate genes and
their response to environmental agents in the
etiology of hypospadias. Nat Clin Pract Urol.
2007; 4(5): 270-279.
9. Gurbuz C, Demir S, Zemheri E, Canat L, Colic
M, Caskurlu T. Is activating transcription factor
3 up-regulated in patients with hypospadias?
Korean J Urol. 2010; 51(8): 561-564.
10. Wang Z, Liu BC, Lin GT, Ln CS, Lue TF,
Willingham E, et al. Up-regulation of estrogen
responsive genes in hypospadias: microarray
analysis. J Urol. 2007; 177(5): 1939-1946.
11. Liu B, Lin G, Willingham E, Ning H, Lin CS,
Lue TF, et al. Estradiol upregulates activating
transcription factor 3, a candidate gene in the
etiology of hypospadias. Pediatr Dev Pathol.
2007; 10(6): 446-454.
12. Beleza-Meireles A, Töhönen V, Söderhäll C,
Schwentner C, Radmayr C, Kockum I, et al.
Activating transcription factor 3: a hormone responsive
gene in the etiology of hypospadias.
Eur J Endocrinol. 2008; 158(5): 729-739.
13. Kalfa N, Liu B, Klein O, Wang MH, Cao M,
Baskin LS. Genomic variants of ATF3 in patients
with hypospadias. J Urol. 2008; 180(5):
2183-2188.
14. Bakin AV, Curran T. Role of DNA 5-methylcyto-
sine transferase in cell transformation by
fos. Science. 1999; 283(5400): 387-390.
15. Li H, Kolluri SK, Gu J, Dawson MI, Cao X,
Hobbs PD, et al. Cytochrome c release and
apoptosis induced by mitochondrial targeting
of orphan receptor TR3 nuclear. Science. 2000;
289(5482): 1159-1164.
16. Liu X, Zhang DY, Li YS, Zing J, He DW, Lin T,
et al. Di-(2-ethylhexyl) phthalate upregulates
ATF3 expression and suppresses apoptosis in
mouse genital tubercle. J Occup Health. 2009;
51(1): 57-63.
17. Miyagawa S, Buchanan DL, Sato T, Ohta Y,
Nishina Y, Iguchi T. Characterization of diethylstilbestrol-
induced hypospadias in female
mice. Anat Rec. 2002; 266(1): 43-50.
18. Baskin LS, Erol A, Jegatheesan P, Li Y, Liu W,
Cunea GR. Urethral seam formation and hypospadias.
Cell Tissue Res. 2001; 305(3): 379-387.
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