THE IMPACT OF THE D727E POLYMORPHISM HAS NO SIGNIFICANT ROLE IN MULTI NODULAR GOITER
Tug E1,*, Sengül N2, Aydin H3, Yilmaz EE2
*Corresponding Author: Esra Tug, M.D., Ph.D., Gazi University, Faculty of Medicine, Department of Medical Genetics, 06500 Ankara, Turkey; Tel.: +90-312-202-69-44; Fax: +90-312-202-46-35; E-mail: esratug@hotmail.com
page: 67

RESULTS

Clinical evaluation of the patients is shown in Table 2. Table 3 shows the distribution of the codon 727 genotypes of the TSHR gene (CG heterozygous; CC wild type) in patients and controls. In addition, the C and G allele frequencies of patient and control groups are given in Table 3. We did not find a homozygous G allele (GG genotype) in our groups. There was no statistically significant difference between the genotype and allele distribution of the two groups (p = 0.417 and p = 0.449, respectively). Moreover, there was no significant difference in family history between the groups with respect to alleles (p = 0.959). However, the subtypes of toxic thyroid disease (toxic and subclinical MNG) were not related to significant differences in polymorphism frequencies compared with the non toxic MNG and control group, while the p.D727E polymorphism is significantly correlated with the low serum level of TSH (p = 0.047).



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