THE IMPACT OF THE D727E POLYMORPHISM HAS
NO SIGNIFICANT ROLE IN MULTI NODULAR GOITER Tug E1,*, Sengül N2, Aydin H3, Yilmaz EE2 *Corresponding Author: Esra Tug, M.D., Ph.D., Gazi University, Faculty of Medicine, Department of Medical
Genetics, 06500 Ankara, Turkey; Tel.: +90-312-202-69-44; Fax: +90-312-202-46-35; E-mail: esratug@hotmail.com page: 67
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RESULTS
Clinical evaluation of the patients is shown in
Table 2. Table 3 shows the distribution of the codon
727 genotypes of the TSHR gene (CG heterozygous;
CC wild type) in patients and controls. In addition,
the C and G allele frequencies of patient and control
groups are given in Table 3.
We did not find a homozygous G allele (GG
genotype) in our groups. There was no statistically
significant difference between the genotype and allele
distribution of the two groups (p = 0.417 and p =
0.449, respectively). Moreover, there was no significant
difference in family history between the groups
with respect to alleles (p = 0.959). However, the subtypes
of toxic thyroid disease (toxic and subclinical
MNG) were not related to significant differences in
polymorphism frequencies compared with the non
toxic MNG and control group, while the p.D727E
polymorphism is significantly correlated with the
low serum level of TSH (p = 0.047).
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