ASSOCIATION BETWEEN OBSESSIVE COMPULSIVE DISORDER AND TUMOR NECROSIS FACTOR-α GENE –308 (G>A) AND –850 (C>T) POLYMORPHISMS IN TURKISH CHILDREN
Lüleyap HU1, Onatoğlu D1, Tahiroğlu AY2, Alptekin D1,*, Yılmaz MB1, Çetiner S3, Pazarbaşı A1, Ünal İ4, Avcı A2
*Corresponding Author: Professor Dr. Davut Alptekin, Department of Medical Biology and Genetics, Medical Faculty, Çukurova University, 01330 Adana, Turkey; Tel.: +90-322-3386060/3498; Fax: +90-322-3386572; E-mail: alptekin@cu.edu.tr
page: 61

RESULTS

The current study was carried out with the aim of defining the effect of mutant genotypes in the progress of OCD. For the –308 polymorphism, 45 of 49 OCD patients’ results were completed. In the OCD patient group, we found four mutant GA genotypes (8.9%) and 41 mutant AA genotypes (91.1%); we did not find any normal GG genotypes. In the control group, five mutant GA genotypes (8.6%) were observed with 53 of genotypes consisting of the normal GG sequence (91.4%) (Table 1). For the –850 polymorphism, 47 of 49 OCD patients’ results were completed. Twenty-five OCD patients had the CT genotype (53.2%), seven patients had the mutant TT genotype (14.9%) and 15 patients had the normal CC genotype (31.9%). In the control group, 19 mutant CT genotypes (32.8%) and seven mutant TT genotypes (12.1%) were found, but the majority (32) consisted of normal CC genotypes (55.2%). Nineteen of the OCD patients (38.8%) were boys and 30 were girls (61.2%). In the control group, 30 children were boys (51.7%) and 28 were girls (48.3%) (Table 1). According to our statistical results, a positive relationship existed between OCD and the –308 polymorphism (p <0.001) but no association was observed between OCD and the –850 polymorphism (p = 0.053). In addition, we determined the ASO titers of the patients. We compared only OCD patients and ASO titers but we did not compare ASO titers of the control group because we only had the ASO titer values of the patients’ group. There exists no positive relationship between ASO titers and the –308 polymorphism (p =0.953) but there was an important significance between the –850 polymorphism and ASO titers (p = 0.010). No positive relationship existed between the genders of the patients and OCD (p =0.180) and no positive association between ASO titers and gender (p = 0.467). For the –850 polymorphism, we made an assumption about the TT genotypes. The TT genotype has a low incidence in the patients’ group (15.0%) and it seemed to reduce ASO titer values, however, this cannot be considered to be a valid comment as patients with normal CC genotypes (32.0%) should also have low ASO titers in their blood (Table 1).



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