ASSOCIATION BETWEEN OBSESSIVE COMPULSIVE
DISORDER AND TUMOR NECROSIS FACTOR-α GENE
–308 (G>A) AND –850 (C>T) POLYMORPHISMS
IN TURKISH CHILDREN
Lüleyap HU1, Onatoğlu D1, Tahiroğlu AY2, Alptekin D1,*,
Yılmaz MB1, Çetiner S3, Pazarbaşı A1, Ünal İ4, Avcı A2
*Corresponding Author: Professor Dr. Davut Alptekin, Department of Medical Biology and Genetics, Medical
Faculty, Çukurova University, 01330 Adana, Turkey; Tel.: +90-322-3386060/3498; Fax: +90-322-3386572;
E-mail: alptekin@cu.edu.tr
page: 61
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RESULTS
The current study was carried out with the aim
of defining the effect of mutant genotypes in the progress
of OCD. For the –308 polymorphism, 45 of 49
OCD patients’ results were completed. In the OCD
patient group, we found four mutant GA genotypes
(8.9%) and 41 mutant AA genotypes (91.1%); we
did not find any normal GG genotypes. In the control
group, five mutant GA genotypes (8.6%) were observed
with 53 of genotypes consisting of the normal
GG sequence (91.4%) (Table 1).
For the –850 polymorphism, 47 of 49 OCD
patients’ results were completed. Twenty-five OCD
patients had the CT genotype (53.2%), seven patients had the mutant TT genotype (14.9%) and 15
patients had the normal CC genotype (31.9%). In the
control group, 19 mutant CT genotypes (32.8%) and
seven mutant TT genotypes (12.1%) were found, but
the majority (32) consisted of normal CC genotypes
(55.2%). Nineteen of the OCD patients (38.8%) were
boys and 30 were girls (61.2%). In the control group,
30 children were boys (51.7%) and 28 were girls
(48.3%) (Table 1). According to our statistical results,
a positive relationship existed between OCD and the
–308 polymorphism (p <0.001) but no association
was observed between OCD and the –850 polymorphism
(p = 0.053). In addition, we determined the
ASO titers of the patients. We compared only OCD
patients and ASO titers but we did not compare ASO
titers of the control group because we only had the
ASO titer values of the patients’ group. There exists
no positive relationship between ASO titers and the
–308 polymorphism (p =0.953) but there was an important
significance between the –850 polymorphism
and ASO titers (p = 0.010). No positive relationship
existed between the genders of the patients and OCD
(p =0.180) and no positive association between ASO
titers and gender (p = 0.467). For the –850 polymorphism,
we made an assumption about the TT
genotypes. The TT genotype has a low incidence in
the patients’ group (15.0%) and it seemed to reduce
ASO titer values, however, this cannot be considered
to be a valid comment as patients with normal CC
genotypes (32.0%) should also have low ASO titers
in their blood (Table 1).
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