MYH ASSOCIATED POLYPOSIS WITH A p.Tyr165Cys MUTATION IN A MOROCCAN PATIENT
Laarabi FZ1,*, Jaouad IC1, El Kerch F1, Sefiani A1,2
*Corresponding Author: Ms. Fatima Zahra Laarabi, Département de Génétique Médicale, Institut National d’Hygiène, 27, Avenue Ibn Battouta, B.P. 769 Rabat, Morocco; Tel.: +212(0)37-77-19- 02; Fax: 212(0)37-77-20-67; E-mail: fz_laarabi@yahoo.fr
page: 65

REFERENCES

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2.Nielsen M, Franken PF, Reinards TH, Weiss MM, Wagner A, van der Klift H, Kloosterman S, Houwing-Duistermaat JJ, Aalfs CM, Ausems MG, Bröcker-Vriends AH, Gomez Garcia EB, Hoogerbrugge N, Menko FH, Sijmons RH, Verhoef S, Kuipers EJ, Morreau H, Breuning MH, Tops CM Wijnen JT, Vasen HF, Fodde R, Hes FJ. Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP). J Med Genet 2005; 42(9): e54.
 3. Al Tassan N, Chmiel NH, Maynard J, Fleming N, Livingston AL, Williams GT, Hodges AK, Davies DR, David SS, Sampson JR, Cheadle JP. Inherited variants of MYH associated with somatic G:C>T:A mutations in colorectal tumors. Nat Genet 2002; 30(2): 227-232
 4.Cleary SP, Cotterchio M, Jenkins MA, Kim H, Bristow R, Green R, Haile R, Hopper JL, LeMarchand L, Lindor N, Parfrey P, Potter J, Younghusband B, Gallinger S. Germline MutY human homologue mutations and colorectal cancer: a multisite casecontrol study. Gastroenterol 2009; 136(4): 1251-1260.
5. Avezzu A, Agostini M, Pucciarelli S, Lise M, Urso ED, Mammi I, Maretto I, Enzo MV, Pastrello C, Lise M, Nitti D, Viel A. The role of MYH gene in ge­netic predisposition to colorectal cancer: another piece of the puzzle. Cancer Lett 2008; 268(2): 308-313.
6. Jones S, Emmerson P, Maynard J, Best JM, Jordan S, Williams GT, Sampson JR, Cheadle JP. Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C>T:A mutations. Hum Mol Genet 2002, 11(23): 2961­2967.
7. Sieber OM, Lipton L, Crabtree M, Hei-nimann K, Fidalgo P, Phillips RK, Bisgaard ML, Omtoft TF, Aaltonen LA, Hodgson SV, Thomas HJ, Tomlinson IP. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 2003, 348(9): 791-799.
8. Isidro G, Laranjeira F, Pires A, Leite J, Re-gateiro F, Castro E, Soares J, Castro C, Giria J, Brito MJ., Medeira A, Teixeira R, Morna H, Gas-par I, Marinho C, Jorge R, Brehm A, Ramos J.S, Boavida MG. Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas. Hum Mutat 2004; 24(4): 353-354.
9. Jaouad IC, Elalaoui SC, Sbiti A, Elkerh F, Belmahi L, Sefiani A. Consanguineous marriages in Morocco and the consequence for the incidence of autosomal recessive disorders. J Biosoc Sci 2009; 41(5): 575-581.



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