Balkan Journal of Medical Genetics

ANGIOTENSIN-CONVERTING ENZYME GENOTYPE AND ACUTE PANCREATITIS IN TURKEY
Kasap E1*, Akyıldız M2, Tekin F2, Akarca U2
*Corresponding Author: Elmas Kasap, Department of Gastroenterology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey; Tel.: +90-236-2330115; +90-542-2457238; Fax: +90- 236-2370213; E-mail: elmaskasap@ yahoo.com
page: 39

RESULTS

The characteristics of the patients with AP and the healthy controls are summarized in Table 1. Etiology and severity of AP are summarized in Table 2. The etiology was classed as biliary in 44, and 24 were classed to be of other etiologies [six hypertriglyceridemia, 10 post endoscopic retrograde cholangiopancreatography procedure (ERCP), three alcoholic, five idiopathic]. Fifty-five patients were diagnosed to have mild AP, 13 patients were diagnosed with severe AP. Thirteen patients with AP had diabetes mellitus (DM) type 2, 23 had essential hypertension (HT), and 10 had both.

Genotype distribution of ACE gene for both groups is summarized in Table 3. The DD genotype was more prevalent among healthy controls than in AP patients, while the II genotype was more prevalent in AP patients than healthy controls (p <0.05).

Genotype distribution of the ACE gene in biliary and in non biliary AP is summarized in Table 4. There was no significant difference in the distribution of the I/D polymorphism or in allele frequency between biliary and non biliary AP.

Genotype distribution of the ACE gene in AP associated with DM and/or HT is summarized in Table 5. There is no significant difference in the distribution of the I/D polymorphism or allele frequency between AP with DM and AP with HT.

However in patients with both these diseases, the ACE II genotype and allele I frequency was significantly higher than in the healthy group or in patients with only one of these diseases (p <0.05). The distribution of ACE genotypes DD and DI were similar in patients with mild or severe AP. However, frequency of the II genotype in severe AP was significantly higher than healthy controls (p <0.05) (Table 6).

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