PROGNOSTIC VALUE OF CYP1A2 (rs2069514 AND rs762551) POLYMORPHISMS IN COVID-19 PATIENTS
Bozkurt I, Gözler T, Yüksel I, Ulucan K, Tarhan KN
*Corresponding Author: Prof.Dr. Korkut Ulucan, Saray, Site Yolu Cd No:27, Umraniye/ Istanbul, Turkey, 34768, email: korkutulucan@hotmail.com.tr; +902164002222
page: 35
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Abstract
The aim of the study was to examine the genotypeallele
determination of CYP1A2 rs2069514 and rs762551
polymorphisms in patients with mild and severe COVID-19
and to determine their effectiveness as prognostic criteria
in COVID-19. The study consists of 60 patients who were
hospitalized in intensive care or outpatient treatment due to
COVID-19 in Istanbul NP Brain Hospital between 2020-
2021. Genotyping was conducted by Real-Time PCR. Age
(p<0.001); chronic disease (p=0.002); cardiovascular disease
(p=0.004); respiratory distress (p<0.001); neurological
disease (p=0.004); fatigue (p=0.048); loss of taste and
smell (p=0.003); nausea/vomiting (p=0.026); intubated
(p<0.001); ground glass image (p<0.001) and CYP1A2
genotypes (p<0.001) showed a statistically significant
difference between patients with and without intensive
care admission. According to multivariate logistic regression
analysis, CYP1A2 *1A/*1C + *1C/*1C genotypes
(OR:5.23 95% CI: 1.22-22.36; p=0.025), chronic disease
(OR:4.68 95% CI:1.14- 19.15; p=0.032) or patients at 65
years or older (OR:5.17, 95%CI:1.26-21.14; p=0.022)
increased the risk of admission to the intensive care unit.
According to our results, we strongly suggest considering
the CYP1A2 rs2069514 and rs762551 polymorphisms as
important predictors of Intensive Care Unit admission in
patients with COVID-19, and we also suggest that genotype
results will guide clinicians for the benefit and the
efficiency of the treatment.
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