UNUSUAL MANIFESTATION OF EXTRAOSSEOUS
EWING SARCOMA: REPORT OF 3 CASES
Ioannidou M.1,*, Tsotridou E.1, Samoladas E.2, Tragiannidis A.1, Kouskouras K.3,
Sfougaris D.4, Spyridakis I.5, Foroulis C.6, Galli-Tsinopoulou A.1, Hatzipantelis E.1
*Corresponding Author: MD Maria Ioannidou, St Kiriakidi 1, Children’s and Adolescent’s Hematology-
Oncology Unit of 2nd Department of Pediatrics, AUTh, AHEPA University General Hospital,
Thessaloniki, Greece. Zip code: 54621. Tel.: 00306942067923. E-mail: ioannidou@auth.gr
page: 77
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Abstract
Ewing sarcoma (ES), described as a diffuse endothelioma
of the bone, is divided into two categories: osseous
and extraosseous, which mainly affects adolescents.
Extraosseous Ewing Sarcomas (EES) are rare tumors
originating from soft tissues. Their clinical presentation
depends mainly on the primary location of the tumor and
are highly chemosensitive and radiosensitive. The purpose
of this study was to describe the clinical characteristics
and outcomes of 3 children with EES and uncommon
presentation treated in our Unit. The diagnosis of EES was
confirmed by biopsy and cytogenetic analysis with fluorescence
in situ hybridization (FISH). Surgical excision
was planned as primary treatment, followed by adjuvant
chemotherapy according to EURO -E.W.I.N.G protocol.
To date, all patients are alive, 1, 3 and 4 years after completion
of treatment, with no signs of recurrence or metastasis.
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