KDM3A, A NOVEL BLOOD-BASED BIOMARKER
IN COLORECTAL CARCINOGENESIS
Polat D.1, Onur E.2,*, Yılmaz N.3, Sökücü M.4, Gerçeker O.F.1
*Corresponding Author: Assoc. Prof. Elif Onur, Department of Medical Biology, Faculty of Medicine,
SANKO University, 27090 Gaziantep, Turkey; Phone:+90 342 211 6562; Fax: +90 342 211
6566; Email: elif.onur@sanko.edu.tr
page: 23
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Abstract
Colorectal cancer (CRC) is one of the leading causes
of cancer-linked deaths globally. The determination of
biomarkers is important in the prognosis and treatment
of CRC. Previous studies emphasized the relationship
between hypoxia and CRC in humans, and there is strong
evidence that this process is strongly related to HIF-1.
KDM3A is a histone demethylase that could directly bind
to HIF-1α, a subunit of HIF-1. This study aimed to reveal
whether the expression level of the KDM3A gene could
be used as a predictor of CRC. The expression levels of
HIF-1α, KDM3A, and Epithelial-Mesenchymal Transition
(EMT) genes were evaluated by qRT-PCR in leukocyte
samples of 50 CRC patients in different stages and 50
healthy controls. HIF-1α and KDM3A expression levels
were significantly higher in the CRC group, compared
to the controls. Slug and ZEB-1 genes, the mesenchymal
markers, showed the same significance pattern between
groups. We acquired 0.664 AUC with 54% sensitivity
and 85.4% specificity for separating controls from CRC
patients by using the KDM3A expression levels in ROC
analysis. This data support that KDM3A could be a novel
supplementary biomarker in diagnosis of CRC, which
could be noninvasively detected in circulation.
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