DUAL EFFECT OF THE GHRL GENE VARIANT IN
THE MOLECULAR PATHOGENESIS OF OBESITY
Becer E1,2, Ergoren MC2,3,*
*Corresponding Author: Associate Professor Mahmut C. Ergoren, Ph.D., Department of Medical
Biology, Faculty of Medicine, Near East University, Near East Boulevard, 99138 Nicosia, Cyprus.
Tel.: +90-392-675-1000, Ext: 3035. Fax: +90-392-223-6461. Mobile: +90-0548-865-8889. E-mail:
mahmutcerkez.ergoren@ neu.edu.tr
page: 27
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Abstract
Obesity is as a global health problem due to its interaction
with complex chronic disorders such as cardiovascular
disorders, type 2 diabetes mellitus (T2DM) and
cancer. Despite the fact that pathogenesis of obesity is not
yet clearly understood, it is associated with a combination
of psychological, environmental and various genetic factors.
Here, employing a case-control design, we aimed to
examine the effects of the GHRL c.152C>T (p.Arg51Gln)
(rs34911341) and c.214G>T (p.Leu72Met) (rs696217)
markers on susceptibility to obesity in a Turkish-Cypriot
population, as well as to evaluate whether these markers
affect biochemical parameters and show their putative
functional consequences. This study involved 211
Turkish-Cypriot subjects (106 obese and 95 non obese).
Genotyping for the GHRL gene polymorphisms was performed
by polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP) analysis. Our results
indicate that the GHRL Leu72Met polymorphism was
found to be significantly higher in obese patients, with
respect to genotypic (p = 0.0012) and allelic (p = 0.0005)
frequencies. Strikingly, the rs696217 GT genotype (heterozygous)
had significantly lower serum high-density
lipoprotein cholesterol (HDL-C) (p = 0.015) than GG (wild
type) genotypes. Overall, Leu72Met susceptibility variant
may be considered as risk and crucial marker for both
obesity and cholesterol metabolism in the community of
Turkish-Cypriots. Thus, the dual effect of the GHRL gene
Leu72Met variant may be used for clinical diagnosis.
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