COMPARATIVE EXPRESSION ANALYSIS
OF HUMAN ENDOGENOUS RETROVIRUS ELEMENTS
IN PERIPHERAL BLOOD OF CHILDREN
WITH SPECIFIC LANGUAGE IMPAIRMENT
Minchev DS1,2,*, Popov NT3, Naimov SI1, Minkov IN4, Vachev TI1
*Corresponding Author: Assistant Professor Danail S. Minchev, Department of Medical Biology,
Faculty of Medicine, Medical University-Plovdiv, 4000, Plovdiv, Bulgaria. Tel: +359-896-313-627.
E-mail: dante17@abv.bg
page: 49
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Abstract
Specific language impairment (SLI) is a psychiatric
condition with a complex etiology and a substantial genetic
basis that affects children’s verbal communication
abilities. In this study, we examined the expression of five
different human endogenous retrovirus elements (HERVs)
in a cohort of 25 children with SLI and 25 healthy children
in the control group. Human endogenous retrovirus
elements, a diverse group of repetitive DNA sequences,
can potentially cause considerable genetic heterogeneity.
They had been integrated in the genome of our ancestors
throughout evolution and now consist of about 8.0% of
the human genome. Several HERV loci are transcribed in
various cell types. Their expression in peripheral blood
and in the brain is altered in many neurological and psychiatric
diseases. To date, HERV expression profiles have
never been studied in patients with SLI. This study aimed
to elucidate differentially regulated human endogenous
retroelements in peripheral blood of children with SLI, in
comparison with healthy controls, through quantitative reverse
tran-scription-polymerase chain reaction (qRT-PCR)
methodology. Our results show that two genes: HERV-K
(HLM-2) gag and HERV-P env were expressed at lower
levels in the blood samples from SLI children in comparison
with those in the control group.
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