ANALYSIS OF THE PPARD GENE EXPRESSION LEVEL CHANGES IN FOOTBALL PLAYERS IN RESPONSE TO THE TRAINING CYCLE.
Domańska-Senderowska D.1*, Snochowska A.1*, Szmigielska P.1,Jastrzębski Z.2, Jegier A.3, Kiszałkiewicz J.1, Dróbka K.1, Jastrzębska J.2, Pastuszak-Lewandoska D.1, Cięszczyk P.4, Maciejewska-Skrendo A.4, Zmijewski P.5, Brzeziańska-Lasota E.1
*Corresponding Author: Piotr Zmijewski, PhD Institute of Sport National Research Institute Ul. Trylogii 2/16 01-982 Warszawa e-mail: zmijewski@op.pl
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Abstract

PPARD gene codes protein that belongs to the peroxisome proliferator-activated receptor (PPAR) family engaged in a variety of biological processes, including lipid metabolism in muscle cells. In this study we assess the relationship between PPARD gene expression and lipid metabolism parameters and the variation of PPARD gene expression before and after two months of training in a group of football players. Peripheral blood lymphocytes were obtained from 22 football players (17.50.7 yr, 1780.7 cm, 68.059.18 kg). PPARD gene expression, analyzed by qPCR, was significantly higher after two months of training (T2) (P = 0.0006). Moreover, at the end of the training cycle, there was a significant decrease in FAT [%] (P=0.01) and FAT [kg] (P = 0.01). A negative correlation was observed between FAT [kg] and PPARD gene expression level in T2 (P = 0.03). The levels of cholesterol and triglyceride fractions were not significantly different (P>0.05) before and after training. No significant relationship between PPARD expression and cholesterol or triglyceride levels was found. We found that physical training affects PPARD expression. Moreover, the negative correlation between PPARD expression and FAT [kg] level may be indicative of the contribution of PPARD in metabolic adaptation to increased lipid uptake, what can be used to control the body composition of athletes.



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