SUSCEPTIBILITY TO ORAL SQUAMOUS CELL CARCINOMA:
CORRELATION WITH VARIANTS OF CYP1A1-MspI, GSTT1,
GSTM1, ALDH2, EC-SOD AND LIFESTYLE FACTORS
Dong T-T, Wang L-J, Liu L-Z, Ma S-N
*Corresponding Author: Mrs. Ting-Ting Dong, General Hospital of Daqing Oil Field, No. 9 Zhongkang Street, Saertu District,
Daqing 163001, Heilongjiang Province, People’s Republic of China. Tel: +86-459-599-4114. Fax: +86-459-580-5247.
Email: tingtingdong_139@163.com
page: 61
download article in pdf format
|
|
Abstract
In order to investigate the association between polymorphisms
in genes encoding metabolizing enzymes (CYP1A1-
MspI, EC-SOD (extracellular superoxide dismutase),
GSTT1, GSTM1, ALDH2), cigarette and alcohol consumption,
and the risk of oral squamous cell carcinoma, we conducted
a prospective case-control study comprised of 750
individuals with oral squamous cell carcinoma (OSCC) and
750 healthy individuals. Data about smoking and drinking
habits were collected along with other demographic and
clinical information. Peripheral blood samples were collected
for DNA extraction, and polymerase chain reaction
(PCR) and PCR-RFLP (restriction fragment length polymorphism)
were used to determine genotypes of CYP1A1,
EC-SOD, GSTT1, GSTM1, ALDH2. The results showed
that smoking and alcohol consumption were significantly
more common among patients than controls (p <0.05).
There were significant differences in the genotype distribution
for each locus between groups, with the CYP1A1 (m2/
m2), EC-SOD (C/G), GSTT1 [–], GSTM1 [–] and ALDH2
(non G/G) genotypes being more common among patients
(p <0.05). Furthermore, the majority of patients had at
least two or more variant genotypes, while controls had
one or no variant genotype (p <0.05). Finally, multiple
variant genotypes combined with smoking, drinking, or
both smoking and drinking significantly increased the risk
of OSCC, with greater increase for heavier smoking/drinking.
In brief, genetic polymorphism of CYP1A1, EC-SOD,
GSTT1, GSTM1, and ALDH2 and smoking and drinking
history are closely associated with susceptibility to OSCC.
|
|
|
|
 |
Number 27
VOL. 27 (2), 2024 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
