POLYMORPHISM OF ANGIOTENSIN-CONVERTING
ENZYME (rs4340) AND DIABETIC NEPHROPATHY IN
CAUCASIANS WITH TYPE 2 DIABETES MELLITUS Šeruga M, Makuc J,, Završnik M, Cilenšek I, Ekart R, Petrovič D M. Šeruga and J. Makuc contributed equally to this study. *Corresponding Author: Professor Dr. Daniel Petrovič, M.D., Ph.D., Institute of Histology and Embryology, Faculty of
Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. Tel: +386-1-543-7360. Fax: +386-1-543-7361.
E-mail: daniel.petrovic@mf.uni-lj.si page: 29 download article in pdf format
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Abstract
Diabetic nephropathy (DN) is the leading cause of endstage
renal disease (ESRD) in developed countries. Several
environmental and genetic factors predict the development
and progression of DN. The renin-angiotensin system was
demonstrated to be involved in the development of DN. We
evaluated the association between rs4340 of the angiotensinconverting
enzyme (ACE) gene and DN in Caucasians with
type 2 diabetes mellitus (T2DM) in 276 Slovenian patients
with T2DM who had DN, and 375 patients without clinical
signs of DN. Genetic analysis was performed with either
standard polymerase chain reaction (PCR) (for rs4340).
Results were analyzed using the χ2 test and multivariate logistic
regression analyses. We found no association between
rs4340 and DN. Cystatin C was significantly higher in the
DN+ group (p <0.001) than in the DN group. Cystatin C
was a better marker for the estimation of renal function than
estimated glomerular filtration rate (eGFR) according to the
modification diet in renal disease (MDRD) equation mL/
min. We concluded that there was no association between
the rs4340 of the ACE gene and DN in Caucasian patients
who have T2DM.
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