INTELLECTUAL ABILITY IN THE DUCHENNE
MUSCULAR DYSTROPHY AND DYSTROPHIN GENE
MUTATION LOCATION
Milic Rasic V1,2,*, Vojinovic D1, Pesovic J3, Mijalkovic G1, Lukic V1, Mladenovic J1,
Kosac A1, Novakovic I4, Maksimovic N4, Romac S3, Todorovic S1, Savic Pavicevic D3
*Corresponding Author: Vedrana Milic Rasic, M.D., Ph.D., Clinic for Neurology and Psychiatry for Children
and Youth, Dr. Subotica 6A, 11000 Belgrade, Serbia. Tel: +381-11-265-8355. Fax: +381-11-264-5064. E-mail:
vedrana.milic.npk@gmail.com
page: 25
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Abstract
Duchenne muscular dystrophy (DMD) is the
most common form of muscular dystrophy during
childhood. Mutations in dystrophin (DMD) gene are
also recognized as a cause of cognitive impairment.
We aimed to determine the association between intelligence
level and mutation location in DMD genes in
Serbian patients with DMD. Forty-one male patients
with DMD, aged 3 to 16 years, were recruited at the
Clinic for Neurology and Psychiatry for Children and
Youth in Belgrade, Serbia. All patients had defined
DMD gene deletions or duplications [multiplex ligation-
dependent probe amplification (MLPA), polymerase
chain reaction (PCR)] and cognitive status
assessment (Wechsler Intelligence Scale for Children,
Brunet-Lezine scale, Vineland-Doll scale). In
37 patients with an estimated full scale intelligence
quotient (FSIQ), six (16.22%) had borderline intelligence
(70
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