MOLECULAR CYTOGENETIC STUDY OF THE NF2 GENE
DELETION IN MENINGIOMA IN SUDANESE PATIENTS AbdElmontalab Farah Y1, Fadl Elmula I2, Abushama HM1, Kreskowski K3, Liehr T3,* *Corresponding Author: Dr. Thomas Liehr, Institut für Humangenetik, Kollegiengasse 10, D-07740 Jena, Germany;
Tel.: 49-3641-935533; Fax: ++49-3641-935582; E-mail: Thomas.Liehr@med.uni-jena.de page: 29 download article in pdf format
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Abstract
Meningioma is the second most common adult
central nervous system tumor. Mutations and/or deletions
within the tumor suppressor gene neurofibromatosis
type 2 (NF2) are associated with meningioma
development and progression. We studied 29 meningioma
samples by cytogenetic analysis and interphase
fluorescence in situ hybridization (I-FISH) using a
locus-specific probe for the NF2 gene region. We
detected loss of the NF2 gene in all samples except
for one. In 10 of the 29 samples, karyotypic analyses
confirmed the I-FISH results and revealed additional
numerical and/or structural rearrangements in nine
of them. Our study confirmed: i) the limited role
of banding cytogenetics in assessing chromosomal
rearrangements in meningioma, as this tumor is hard
to be grown in cell culture; ii) we could show that
two-color I-FISH is well-suited for NF2-deletion
screening. Our results were in accordance with those
of comparable studies, even though the frequency of
97.0% of meningiomas with NF2 deletions is exceptionally
high in the studied Sudanese patients.
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