DETECTING SEX-BIASED GENE FLOW IN AFRICANAMERICANS THROUGH THE ANALYSIS OF INTRA- AND INTER-POPULATION VARIATION AT MITOCHONDRIAL DNA AND Y- CHROMOSOME MICROSATELLITES
Battaggia C1, Anagnostou P1,3, Bosch I4, Brisighelli F4, Destro-Bisol G1,3, Capocasa M2,3,*
*Corresponding Author: Dr. Marco Capocasa, Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Università “La Sapienza”, Roma, Italy, P.le A. Moro 5, 00185 Roma, Italia; Tel.: +39-6-4991-2725; Fax: ++39-6-4991-2771; E-mail: marco.capocasa@uniroma1.it
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Abstract

This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European malebiased gene flow. We show that comparisons of intraand inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.



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