MOLECULAR GENETICS OF BREAST AND OVARIAN CANCER: RECENT ADVANCES AND CLINICAL IMPLICATIONS
Bogdanova N1,2, Dörk T2,*
*Corresponding Author: Thilo Dörk, Ph.D., Hannover Medical School, Gynaecology Research Unit (OE 6411), Carl-Neuberg-Str. 1, D-30625 Hannover, Germany; Tel.: +49-511-532-6075; Fax: +49-511-532- 6081; E-mail: doerk.thilo@mh-hannover.de
page: 75
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Abstract

Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy.



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