OP04. RELATIONS BETWEEN EGFR, PTEN, PDGFR-α, MGMT EXPRESSION PATTERNS AND TP53 AND P53 PATHWAY (MDM-2 AND P14ARF) GENE ABERRATİONS IN LOW GRADE GLIOMAS
EREN P.1, Bozkurt S.2, Kılıç T.3, Turan K.4, Erdağ B.5, Sav A2., Pamir M.N 3., Çırakoğlu B1. 1. Marmara University Faculty of Medicine Department of Medical Biology and Genetics 2. Marmara University Institute of Neurological Sciences Department of Pathology, 3. Marmara University Faculty of Medicine Department of Neurosurgery, 4. Marmara University Faculty of Pharmacology Department of Pharmaceutical Biotechnology, 5. Scientific and Technical Research Council of Turkey, Marmara Research Center email: pinaren@yahoo.com; pinaren@gmail.com
*Corresponding Author:
page: 36

Abstract

The differentiation and growth signal transmitting PDGFR-α, EGFR, their active downstream effectors and PTEN protein suppressing these pathways creates faith of glioma cells. Determination of these molecular aberrations could help verifying the diagnosis of low grade gliomas by genetics and reviewing of histopathological diagnosis in this histologically complex tumour group. Not only to get support of the diagnosis but also to get an opinion about the prognosis of the disease could be possible. In this study, patient group was composed of fortyeight low grade glioma patients diagnosed between April 1999- January 2005 and had glioma surgery. Following DNA isolation p53 mutations are detected by SSCP technique. mdm2 amplifications and P14 deletions are studied with multiplex PCR technique. At the same time expression of P53, MGMT, EGFR, PDGFR-α and PTEN proteins are determined immunohistochemically. Fourthyeight cases of this study were composed of 12 Astrocytomas, 16 Oligodendrogliomas and 20 Oligoastrocytomas histopathologically and 22 patients of the total group had p53 mutations. Among the histological subgroups PDGFR-α, EGFR, PTEN expressions are found to be different and their expression in astrocytomas and oligoastrocytomas are found to be increased. Furthermore according to tumour location MGMT and P53 ekspressions were different.




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