HUMAN SEMINAL PLASMA PROTEOME STUDY: A SEARCH FOR MALE INFERTILITY BIOMARKERS
Davalieva K1,*, Kiprijanovska S1, Noveski P1, Plaseski T2, Kocevska B2, Plaseska-Karanfilska D1
*Corresponding Author: Dr. Katarina Davalieva, Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov,” Macedonian Academy of Sciences and Arts, Krste Misirkov 2, 1000 Skopje, Republic of Macedonia; Tel.: +389-2-3235-410; Fax: +389-2-3115-434; E-mail: katarina@manu.edu.mk
page: 35
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Abstract

Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of highthroughput MS-based techniques. Of special interest in the field of male infertility biomarkers, is the identification and characterization of differentially expressed proteins in seminal plasma of men with normal and impaired spermatogenesis. However, the data obtained until now is still quite heterogeneous and with small percentage of overlap between independent studies. Extensive comparative analysis of seminal plasma proteome is still needed in order to establish a potential link between seminal plasma proteins and male infertility.



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