NATIONAL REFERENCE CENTRE FOR GENOMICS
AND PROTEOMICS — MACPROGEN
Plaseska-Karanfilska D*
*Corresponding Author: Professor Dr. Dijana Plaseska-Karanfilska, Research Centre
for Genetic Engineering and Biotechnology “Georgi D. Efremov,” Macedonian Academy of Sciences and
Arts, Krste Misirkov 2, Skopje 1000, Republic of Macedonia; Tel: +389(0)2 3235410; Fax: +389 (0)2
3115434; E-mail: dijana@manu.edu.mk
page: 1
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Abstract
The “National Reference Centre for Genomics
and Proteomics” (MACPROGEN) was financed by
the European Commission within the FP7 Capacities
Work Program for a period of 3 years, starting April
1 2009. The MACPROGEN project aimed at upgrading
and improving the capacity of the Research
Centre for Genetic Engineering and Biotechnology
(RCGEB) “Georgi D. Efremov,” Macedonian
Academy of Sciences and Arts (MASA), Skopje,
Republic of Macedonia, for research and education
in the fields of genomics and proteomics. The main
objectives of the project were to establish a technological
platform for high throughput genomics and
proteomics research, networking with European
Union (EU) research institutions in order to foster
collaborative activities, disseminating knowledge
and expertise and ultimately building an interactive
and competitive research environment. Altogether,
the realization of MACPROGEN objectives was
contributing to the strengthening of Macedonian research,
technology and development capacities and
enhancing career opportunities for Macedonian scientists.
The RCGEB is one of the few institutions from
the Republic of Macedonia that met the criteria
for a center of excellence due to its esteemed scientific
and educational record in life sciences. The
RCGEB was founded in 1987 as a research unit of
MASA with the main goal of advancing scientific
knowledge in the field of protein chemistry, molecular
biology, genetic engineering and biotechnology
through research, practical training of scientists and
postgraduate studies. Under the guidance of the
late Academician Georgi D. Efremov, the founder
and Director of RCGEB until his death in May
2011, the RCGEB became a hub for research in the
field of biomolecular sciences in the Republic of
Macedonia. It was one of the first institutions in the
region that applied these new technologies in molecular
diagnostics of human diseases and became
an international center for training in basic and
advanced methods in these sciences. Immediately
after his death, the Presidency of MASA renamed
the center in his honor, as the Research Centre for
Genetic Engineering and Biotechnology “Georgi D.
Efremov.” In the past 25 years, the RCGEB scientists
have published over 150 papers in international
and national journals, as well as several chapters in
books and monographs. The RCGEB collaborates
with numerous institutions from the Republic of
Macedonia, medical institutions from neighboring
countries and many academic institutions from different
countries worldwide.
The main research interest at the RCGEB during
the past 25 years has been molecular characterization
of the most common monogenic diseases, with
a special emphasis on hemoglobinopathies, as well
as some aspects of the molecular epidemiology of infectious diseases, genetics of the most common
malignancies and DNA markers for human identification.
The upgrading of the RCGEB infrastructure
by MACPROGEN funds has enabled widening of
the research objectives toward larger scale investigations
of monogenic diseases and also shifting our
research interest toward comprehensive studies of
some common complex diseases such as cancers,
infertility, mental retardation and deafness by high
throughput genomic and proteomic technologies.
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