INTERLEUKIN-18 PROMOTER GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH MYOCARDIAL INFARCTION IN TYPE 2 DIABETES IN SLOVENIA
Kariž S1*, Petrovič D2
*Corresponding Author: Stojan Kariž, Department of Internal Medicine, General Hospital Izola, Polje 35, Izola 6310, Slovenia; Tel.: +386-5-660-6480; Fax: +386-660-6305; E-mail: stojan.kariz@siol.net
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Abstract

Type 2 diabetes is a major risk factor for myo- cardial infarction (MI) and chronic inflammation may play a central role in both diseases. Interleukin (IL)-18 is a potent proinflammatory cytokine, which is consid- ered important in acute coronary syndromes and type 2 diabetes. We investigated the association of the 137 (G>C), polymorphism (rs187238) and the 607 (C>A) polymorphism (rs1946518) of the IL-18 gene pro- moter region in 495 Caucasians with type 2 diabetes, of whom 169 had MI and 326 subjects had no clini- cally evident coronary artery disease (controls). We also investigated the impact of these polymorphisms on the serum IL-18 level in subsets of both groups and in a normal group. Genotype distributions of the poly- morphisms showed no significant difference between cases and controls. However, IL-18 serum levels were significantly lower in diabetics with the137 CC geno type than in those with other genotypes (241.5 132.7 ng/L vs. 340.2 167.4 ng/L; p <0.05). High sensitivity C-reactive protein and IL-18 serum levels were higher in diabetics in the MI group than in the control group. We conclude that these IL-18 promoter gene polymor- 1 Department of Internal Medicine, General Hospital Izola, Polje 35, Izola 6310, Slovenia 2 Institute of Histology and Embryology, Medical Faculty, Slovenia phisms are not risk factors for MI in Caucasians with type 2 diabetes.



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