COPY NUMBER CHANGES IN 1q21.3 AND 1q23.3 HAVE DIFFERENT CLINICAL RELEVANCE IN OVARIAN TUMORS
Dimova I1, Orsetti B2, Theillet Ch.2, Dimitrov R.3, Toncheva DI1,*
*Corresponding Author: Draga I. Toncheva, Department of Medical Genetics, Medical Faculty, Medical University, 2 Zdrave str. SBALAG “Maichin dom,” 6 Fl., 1431, Sofia, Bulgaria; Tel./Fax: +35-92-952-0357; E-mail: dragatoncheva@yahoo.com
page: 29
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Abstract

Many studies have reported aberrations such as amplifications, deletions and translocations of 1q21-q23 in ovarian tumors. These findings increase the scientific interest in analyzing this region using spe­cific gene probes. We investigated the frequency of copy number changes of two specific bacterial ar­tificial chromosomes (BAC) clones in 1q21.3 and 1q23.3 by fluorescent in situ hybridization (FISH) on tissue microarrays consisting of 540 ovarian tu­mors of different malignancies, histology, stage and grade. Such changes in 1q21.3 were established in 9.64% ofmalignant (2.41% amplification), in 8.33% of low malignant potential (LMP) and in 13.13% of benign ovarian tumors. Copy number changes of 1q23.3 were found in 17.78% of malignant (1.48% amplification), in 16.67% of LMP and in 12.64% of benign ovarian tumors. We found a significantly higher gain of 1q23.3 in non epithelial (50%) com­pared to epithelial tumors (14.73%) (p <0.03). The gain of 1q21.3 prevailed in non serous malignant and LMP ovarian tumors in comparison to serous tumors. In non serous tumors, both gains were as­sociated with higher grade. The frequency of gain in 1q23.3 was 2.5-times higher than that in 1q21.3 of ovarian cancers.

Key words: Ovarian cancer, Copy number changes, Bacterial artificial chromosomes (BAC) clones, Fluorescent in situ hybridization (FISH), Tissue microarray (TMA)
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Department of Medical Genetics, Medical University of Sofia, Sofia, Bulgaria
Laboratory "Identity and Plasticity of Tumors", INSERM, Montpellier, France
Second Gynecologic Clinic, University Hospital of Obstetrics and Gynecology "Maichin dom", Sofia, Bulgaria
 



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