WEB-BASED SOFTWARE FOR STORAGE, STATISTICAL PROCESSING AND ANALYSIS OF SNP DATA IN STUDIES ON COMPLEX DISORDERS
Betcheva E1, Betchev C2, Toncheva DI1,*
*Corresponding Author: Professor Draga Ivanova Toncheva, M.D., Ph.D., Department of Medical Genetics, Medical Faculty, Medical University, 2 Zdrave str., SBALAG “Maichin dom”, 6 Fl., 1431 Sofia, Bulgaria; Tel./Fax: +35-92-952-0357; E-mail: dragatoncheva@yahoo.com
page: 9
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Abstract

Single nucleotide polymorphisms (SNPs) have become a very powerful tool for molecular genetics studies. Public databases provide information on over 10 million polymorphisms in the human genome. The candidate gene approach and genome-wide association studies through SNP analysis have opened a new avenue for defining the genetics of complex disorders. However, analysis of large numbers of SNPs is time-consuming, cost-intensive, and requires huge experimental and statistical resources in association studies. We have developed a web-based product that facilitates the processing and statistical analysis of SNP-genotyping data for case-control association studies and provides for custom design, a structured database and practical export layout. Here we describe the software product database and how it helps in high-speed comprehensive SNP analysis.

Key words: Association study; High-throughput genotyping; Information technology (IT); Multifactorial (complex) disorders; Single nucleotide polymorphisms (SNPs); Web-based software
 

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1 Department of Medical Genetics, Medical University, Sofia, Bulgaria
2 Department of Menagement and Marketing, Technical University, Varna, Bulgaria



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