PS17. GENETIC ASPECTS OF AGING AND GENETIC PASS
VLADISLAV S BARANOV, Helena Baranova* Ott’s Institute of Obstetrics & Gynecology; Russian Academy for Medical Sciences, St Petersburg, Russia; *European Expert Genetics, Biotechnology and Life Sciences for Health, France e-mail: baranov@VB2475.spb.edu
*Corresponding Author:
page: 24

Abstract

Conspicuous achievements in human genome deciphering, genetic polymorphism testing and  comprehension of genetic expression profiles are in line with long known notion that the aging should be treated as a by-product of individual developmental genetic program. It has also become quite evident that each human possesses its own aging program. Moreover detailed analysis of individual aging discovered that each tissue and organ of any subject  ages differently. Thus wide range of  ages exists in anyone’s person body at the same time. No doubt that individual aging mosaicism has its own genetic background. The first but rather impressive steps of  predictive medicine indicate that individual genetic program of aging could be modified  if one knows the genes of individual susceptibility. Many genes of longevity are already identified. According to their functions they could be attributed to energy  and  lipid metabolisms, immunological, cardiovascular and detoxification systems. Gene nets and predictive genetic testing are already operative for a number of multifactorial diseases accompanying aging such as osteoporosis, oncology, cardiovascular diseases as well as bronchial asthma, diabetus mellitus , some autoimmune disorder. 

The genes already known to be associated with longevity are participating in lipid metabolism (APOE, APOB, APOA1,ALOX-5) glucose metabolism (Tyrosine Hydroxylase- Insulin - Insulin growth factors (IGF2)- its receptor rIGF), in the cell energy  machinery ( mitochondrial H haplotype, Bcl2 gene),  anticancer activity ( p53), blood pressure (ACE, AGT, etc), blood coagulation regulation (FV, FII , PAI 1) etc.  Gene testing might be quite reawarding in further advances of anti-aging program. The report highlights present achievements of personalized anti-aging medicine and its impact into longevity and aging. Special attention is paid to the gene nets of cardiovascular diseases, renin-angiotensin system, diabetus mellitus, osteoporosis etc. Polymorphic variants of at least some particular genes such as ACE, AGT, PAII, MTHFR, APOE, also as metabolic genes, like GSTs and other oxidative stress markers (NOS)  are considered as the most plausible candidates of  the genes crucial for aging. Molecular analysis of these particular genes supplemented with the testing of  relevant metabolic  genes, responsible for  efficiency of detoxification system might  have substantial contribution into personalyzed anti - aging  medicine.  Relevant gene testing supplemented with its adequate sophisticated interpretation and constructive recommendations addressed both to the patient and his physician might have substantial contribution to human health and should be considered as a new highly promising approach of the present anti-aging medicine. Individual DNA data bank reflecting increased  personal susceptibility to these common disorders is called “Gene –pass”. Significant progress for its practical application could be achieved through wide scale biochip technology. The later are already available or are in progress for a number of multifactorial diseases. Special attention is paid to genetic form of reproductive health – a version of genetic pass for pregnant woman. Life in harmony with your genes remains indispensable prerequisite of longevity.




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