ORGANOCHLORIDE PESTICIDES IN MACEDONIAN GIRLS WITH PREMATURE SEXUAL DEVELOPMENT
Krstevska-Konstantinova M1,*, Kocova M1, Charlier C2, Bourguignon JP3
*Corresponding Author: Dr. Marina Krstevska Konstantinova, Pediatric Clinic, Department of Endocrinology and Genetics, Medical Faculty, Vodnjanska 17, 1000 Skopje, Republic of Macedonia; Tel.: +389-2-314-7474; Fax: +389-2-3225-809; E-mail: marina@lancom.com.mk
page: 43

Abstract

Premature sexual development (PSD) in girls describes the appearance of secondary sexual signs before the age of 8 years. Early puberty is diagnosed if pubertal signs appear between the age of 8 and 9 years. We found a positive association between the levels of organochloride pesticides (p,p-DDE) in precocious puberty in girls adopted from developing countries and significantly higher levels than in native Belgian girls with the same condition.

We have compared the serum levels of eight p,p-DDE in 56 Macedonian girls with PSD and a control group of 24 normal, age-matched girls, using a gas chromatographic analyzer coupled to a tandem mass spectrometer detector. Of the 56 girls with PSD, 42 had premature thelarche, five had early puberty, and nine had precocious puberty of idiopathic (n = 8) or organic (n = 1) origin. We found traces of p,p-DDE in nine girls (16%) and negative results in 41 (73%), while the remaining six (10%) had a mean level of 1.17 0.7 mg/L. In the control group, traces were found in one girl (4%) and negative results in 18 (75%), while the remaining five (20%) had a mean level of 1.18 0.6 mg/L. We found elevated levels of lindane in the girls with PSD (mean value 1.2 0.8) and significantly higher levels in the control group (1.4 0.8) (p <0.05). We concluded that Macedonian girls with PSD do not have higher levels of p,p-DDE in their serum than the normal controls. However, the elevated levels of lindane in this population should be further investigated.

Key words: Organochloride pesticides (p,p-DDE); Premature sexual development (PSD)

__________________________________________________

1 Pediatric Clinic, Department of Endocrinology and Genetics, Name of Institution?, Skopje, R. Macedonia

2 Laboratory of Toxicology, University of Liege, C.H.U. Sart Tilman, Liege, Belgium

3 Division of Ambulatory Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Liege, C.H.U. Sart Tilman, Liege, Belgium




Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006