A STRATEGY FOR THE CHARACTERIZATION OF SMALL SUPERNUMERARY MARKER CHROMOSOMES (SMC)
Liehr T*, Nietzel A, Weise A, Mrasek K, von Eggeling F, Claussen U, Starke H
*Corresponding Author: Dr. Thomas Liehr, Institut für Humangenetik, Postfach, D-07740 Jena, Germany; Tel: +49-3641-935533; Fax. +49-3641-935502; E-mail: i8lith@mti.uni-jena.de
page: 69

Abstract

The origin of small supernumerary marker chromo­somes (SMC) is nearly impossible to establish by routine cytogenetics alone, while fluorescent in situ hybridization (FISH) methods are highly suited for that purpose. How­ever, a 24-color-FISH approach, using whole chromosome painting (WCP) probes, can only be used successfully for the determination of the markerís chromosomal origin if it is larger than 17p, thus, smaller SMC found in clinical cytogenetics in 0.01-0.05% often cannot be characterized. This paper suggests a strategy for the characterization of small SMC using recently established methods such as centromere specific multicolor FISH (cenM-FISH) or multicolor banding (MCB).

Key words: Supernumerary marker chromosomes (SMC); Fluorescent in situ hybridization (FISH); Strategy for characterization, Uniparental disomy (UPD).




Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006