GENETIC PREDISPOSITION TO PRE-ECLAMPSIA: POLYMORPHISM OF GENES INVOLVED IN REGULATION OF ENDOTHELIAL FUNCTIONS
Mozgovaia EV, Malysheva OV, Ivashchenko TE, Baranov VS*
*Corresponding Author: Professor Dr. Vladislav S. Baranov, Laboratory of Prenatal Diagnosis of Inherited Disorders, D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya line 3, St. Petersburg 199034, Russia; Tel/Fax: +07-812-328-0487; E-mail: baranov@vb2475. spb.edu
page: 19

Abstract

Polymorphisms of six genes that participate in the regulation of endothelial functions (PLAT, PAI-1, ACE, eNOS, TNF-a and GSTP1) were studied in 122 pregnant women with pre-eclampsia (PE) of various forms and se­verity, and in 73 healthy pregnant women. Distribution of relevant genotypes among different groups of affected women was non random and was associated with severity of PE and of accompanying diseases. A clear-cut correla­tion of certain genotypes was found in PE patients with a history of previous vascular complications, and in women with pure but not severe PE. Besides the eNOS and PAI-1 genes, no significant correlation of other gene polymor­phisms with pure severe forms of PE was found.

Key words: endothelial dysfunction; gene polymor­phism; pre-eclampsia (PE); pure PE (pPE); combined PE (cPE).




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