G870A POLYMORPHISM IN THE CYCLIN D1 GENE IN COLORECTAL CANCER
Stefanovska A-M1, Josifovski T2, Panovski M2, Jasar D3, Zografski G3, Popevska Z4, Efremov GD1, Dimovski AJ1,*
*Corresponding Author: : Dr. Aleksandar J. Dimovski, Macedonian Academy of Sciences and Arts, Research Center for Genetic Engineering and Biotechnology, Av. Krste Misirkov 2, POB 428, 1000 Skopje, Republic of Macedonia; Tel: +3892-120253; Fax: +3892-115434; E-mail: aleks@manu.edu.mk *Current address: Faculty of Pharmacy, Vodnjanska 17, 1000 Skopje, Republic of Macedonia; Tel: +3892 119694; FAX: + 3892 123054; E-mail: adimovski@baba.ff.ukim.edu.mk
page: 27

Abstract

The CCND1 gene encodes cyclin D1, which is a key regulatory protein in the transition from the G1 to S phase of the cell cycle. Amplification of CCND1 and over-expression of cyclin D1 were found in a variety of cancers, especially colorectal cancer. There are conflicting reports about the influence of the G870A polymorphism in the CCND1 gene on colorectal carcinogenesis . We evaluated the allelic frequencies and genotype distribution of this variant in a group of 167 colorectal cancer patients from the Republic of Macedonia, and compared it to those of the control subjects from the same population. Our data indicate that the CCND1 polymorphism may influence age at onset of colorectal cancer in young patients only when their tumors exhibit a microsatellite instability (MSI) phenotype.

 

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1      Macedonian Academy of Sciences and Arts, Research Center for Genetic Engineering and Biotechnology, 1000 Skopje, Republic of Macedonia

2      Institute for Oncology, Faculty of Medicine, 1000 Skopje, Republic of Macedonia

3      Clinic for Abdominal Surgery, Faculty of Medicine, 1000 Skopje, Republic of Macedonia

4      Department for Informatics, Faculty of Natural and Mathematical Sciences, 1000 Skopje, Republic of Macedonia

 

 




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