ASSOCIATION STUDY OF THE SEROTONIN 2A AND 1B RECEPTOR GENES WITH SUICIDAL BEHAVIOR IN TWO DIFFERENT POPULATIONS FROM RUSSIA
Gaysina D1,*, Jurjev E1, Gabdulhatov R2, Khusnutdinova E1
*Corresponding Author: Mrs. Daria Gaysina, Department of Human Genomics, Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences; 69 Octyabrya Avenue, Ufa 450054, Russia; Tel.: +7-3472-356088; Fax: +7-3472-356100; E-mail: dgaisina@mail.ru
page: 51

Abstract

Suicidal behavior has been associated with sero­tonergic dysfunction and is partially genetic. This study examined the association of the HTR2A gene A1438G and the HTR1B gene G861C polymorphisms with suicide attempts in Russian and Tatar patients. One hundred and 88 attempted suicide patients and 272 healthy volunteers were investigated. Both polymorphisms were genotyped using the polymerase chain reaction (PCR) method and subsequent enzyme digestion. This study suggests that both the HTR2A and HTR1B genes are likely to be in­volved in the biological susceptibility to suicide. Popula­tion differences between Russian and Tatar subjects in the allele and genotype frequency distribution of both poly­morphisms were shown. In Tatar patients the allele A of the A1438G polymorphism of the HTR2A gene [c2 = 4.65; df = 1; p = 0.025; odds ratio (OR) = 1.54; 95% confident intervals (CI) = 1.03-2.31], in Russian patients the G/G genotype (c2 = 14.76; df = 1; p = 0.0007; OR = 2.83; 95% CI = 1.63-4.91) and the allele G (c2 = 9.81; df = 1; p = 0.002; OR = 1.88; 95% CI = 1.24-2.84) were associated with suicidal behavior.

Key words: Association study; Serotonin 2A (HTR2A); Serotonin 1B (HTR1B); Candidate genes; Polymorphism(s); Serotonin receptor genes; Suicide at­tempts.

 

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1 Department of Human Genomics, Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sci­ences, Ufa 450054, Russia

2 Department of Anaesthesiology and Reanimathology, Bashkir State Medical University, Ufa 450000, Russia

 




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