MOLECULAR GENETIC ABNORMALITIES OF HEAD AND NECK CANCER
Koynova D*
*Corresponding Author: Denitsa Koynova, Department of Medical Genetics, Institute of Obstetrics and GynecolŽogy, Medical University of Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria; Tel.: +359-2-952-03-57; Fax: +359-2-952-03-57; E-mail: dkkoiniva@hotmail.com
page: 45

Abstract

Head and neck cancers are a heterogeneous group of diseases. The development of these tumors is a conse­quence of genetic mutations which influene the activity of oncogenes such as CCND1, c-myc, erbB and ras, as well as the function of tumor suppressor genes: p53, Rb, p16, p21, and p27. The investigation of these genetic changes has been done through the application of a variety of ge­netic methods. The knowledge of the genetic changes which occur in the mucosa of the head and neck region through the different steps of tumorogenesis is very impor­tant for both patient and diagnosis and treatment.

Key words: Head and neck tumors; Head and neck squamous cell carcinoma (HNSCC); Oncogenes; Tumor suppressor genes.




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