LOW INCIDENCE OF BCR-ABL TRANSCRIPTS IN ESSENTIAL THROMBOCYTHEMIA
Panovska I, Pavkovic M, Cevreska L, Efremov DG*
*Corresponding Author: Dimitar G. Efremov, M.D., Ph.D., Associate Professor of Medicine, Department of Hematology, Faculty of Medicine, Vodnjanska 17, 1000 Skopje, Republic of Macedonia; Tel: +389-2-147775; Fax: +389-2-110548; E-mail: defremov@mt.net.mk
page: 17

Abstract

Contradictory observations have been reported regard­ing the expression of BCR-ABL transcripts in patients with essential thrombocythemia (ET). To further address this issue we investigated the presence of BCR-ABL tran­scripts in 56 consecutive patients with ET. Detection of BCR-ABL transcripts coding for the p210 protein was performed by reverse transcriptase-polymerase chain reac­tion (RT-PCR) on total RNA extracted from bone marrow and peripheral blood samples. BCR-ABL transcripts were detected in only two patients (3.6%), who did not differ in any clinical or laboratory feature from the BCR-ABL-negative patients. Our finding that BCR-ABL transcripts are present in only a minority of patients with ET argues against a significant involvement of the BCR-ABL gene in the pathogenesis of ET.

Key words: BCR-ABL; Essential thrombocythemia (ET); oncogenes.




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