PP174. THE EFFICIENCY OF SUBSTITUTIVE HORMONAL THERAPY OF FEMOSTON BY DYSGENESIS OF GONADS
MALIKOVA RANO MUMINOVNA Samarkand State Med. Inst., the Department of obstetrics and gynecology of the pediatric faculty, Uzbekistan e-mail: niholm@rambler.ru
*Corresponding Author:
page: 125

Abstract

The digenesis of gonads is a rare enough genetic pathology, revealing at 1 on 10-12 thousand live-born children. The principles of treatment of the given pathology are known rather for a long time, but there is no precise circuit substitutive hormonal of therapy at the various forms the digenesis of gonads.

Goal. To value the efficiency of Femoston by the digenesis of gonads.

Materials and methods. We examined 50 female patients in age of 12 – 23 with various forms of digenesis of gonads. We made the complex clinical and laboratory investigation.

Results and conclusions. On cariotype we determined that Swyer’s syndrome – 5 (10 %) – 46,XY; mixed form (45,XO/46,XY) – 1 (2 %), typical form or Shereshevsky-Turner’s syndrome (45,XO) – 7 (14 %), mosaic form (45,XO/46,XX) – 7 (14 %), pure form (46,XX) – 30 (60 %).

Comparison of hormonal parameters of the patients with the digenesis of gonads after traditional cyclic and modified hormonotherapy

Summing up discussion of various kinds of hormonotherapy, it is necessary to emphasize the expressed advantages of purpose patients with the various forms of digenesis of gonads of preparations containing natural female sexual hormones 17? - estradiol as a preparation Femoston. 

 

 

Groups

A kind of medical influence

FSH

LH

Estradiol

Progesterone

mME/ml

pmol/l

nmol/l

I

n = 17

 

Starting

Ethinyl estradiol

58,1 ± 4,3

25,8 ± 2,61

29,82±5,69

12,2 ± 1,25

156,3 ± 9,8

175,3±10,0

1,6 ± 0,12

2,62 ± 0,46

II

n = 10

 

 

Regulon

70,8 ± 3,5

14,8 ± 2,0

 

14,3 ± 0,32

8,8 ± 1,13

 

144,8 ± 12,0

194,9 ± 13,0

 

1,75 ± 0,15

3,02 ± 0,68

 

III

n = 23

 

Femoston

108 ± 10,5

15,9 ± 1,8

 

11,2 ± 0,25

9,3 ±  0,95

 

165 ± 12,8

265,3±14,6

 

2,0 ± 0,22

3,1 ± 0,68

 




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