PP155. KILLER IG-LIKE RECEPTOR (KIR) GENE POLYMORPHISM IN THE MACEDONIAN POPULATION
ELI SPIROSKA, Slavica Hristomanova, Dejan Trajkov, Todor Arsov, Aleksandar Petlichkovski, Ana Strezova, Olivija Efinska-Mladenovska, Mirko Spiroski Institute of Immunobiology and Human Genetics, Faculty of Medicine, University St. Kiril and Metodij, Skopje, Republic of Macedonia e-mail: elispiroska@yahoo.com
*Corresponding Author:
page: 117

Abstract

The aim of this study was to analyze Killer Ig-Like Receptor (KIR) Gene Polymorphism in the Macedonian Population. The Macedonian population consists of 214 healthy unrelated individuals, aged 20-35 years. All individuals are of Macedonian origin and nationality, Christian Orthodox religion, and residents of the geographical areas of different regions of the Republic of Macedonia. The spoken language is Macedonian. Blood samples were collected after written consent, DNA was isolated from peripheral blood leukocytes by the phenol-chlorophorm extraction method. PCR-based method designed to detect the presence and absence of KIR genes was used (The PEL-FREEZ KIR Genotyping SSP Kit). The population genetics analysis package, Arlequin, was used for analysis of the data. All 17 KIR genes were observed in the Macedonian population and framework genes 3DL3, 2DL4, and 3DL2 were present in all individuals. We found 56 KIR genotypes. The gene expression frequency of KIR was: 2DL1 (0.94), 2DL2 (0.59), 2DL3 (0.89), 2DL5 (0.41), 3DL1 (0.93), 2DP1 (0.98), 2DS1 (0.48), 2DS2 (0.56), 2DS3 (0.36), 2DS4 (0.94), 2DS5 (0.30), 3DS1 (0.39), 3DP1 (0.99), respectively. Most of individuals (99.5%) had 3DP1; 99% had 3DP1*003, and 24% had 3DP1*001/002. In 41% of individuals we found 2DL5; 28% had 2DL5A*001, and 25% had 2DL5B*002/004. In 94% of individuals we found 2DS4; 25% had 2DS4*001-002, and 85.9% had 2DS4*003. The frequency of KIR loci in Macedonian population shares several general futures with other Caucasoid populations studied before.

 




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