PP146. RECURRENT MISCARRIAGES AND MATERNAL THROMBOPHILIA IN SERBIAN POPULATION
V. DJORDJEVIC1, LJ. Rakicevic1, B. Tomic1, P. Miljic2, D. Mikovic3, M. Kovac3, N. Antonijevic4, D. Radojkovic1 1. Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia and Montenegro 2. Institute of Hematology, University Clinical Center of Serbia, Belgrade, Serbia and Montenegro 3. Hemostasis Department and Hemophilia Center, National Blood Transfusion Institute, Belgrade, Serbia and Montenegro 4 Institute of Cardiovascular Diseases, University Clinical Center of Serbia, Belgrade, Serbia and Montenegro e-mail: qwert@eunet.yu
*Corresponding Author:
page: 113

Abstract

Recurrent fetal loss is a frequent health problem, affecting up to 5% of women in the reproductive age. Thrombophilia, a multifactorial disorder in which acquired and genetic risk factors may play important roles, has been linked to increased risk of pregnancy loss. The most frequent genetic risk factors are: factor V G1691A (FV Leiden), factor II G20210A (FII G20210A) and methylenetetrahydrofolate reductase C677T (MTHFR C677T) mutation. Aim of our study was to establish the prevalence of these genetic risk factors in group of 70 women with two or more idiopathic pregnancy losses. Patients with antithrombin III, protein C or protein S deficiency or malignancy were excluded from the study. The mutations were detected by polymerase chain reaction, followed by digestion with specific restriction enzymes. Normal and mutated alleles were distinguished by the size of the restriction fragments, using polyacrylamide gel electrophoresis. For the FV Leiden mutation 10 heterozygous carriers where identified, giving the frequency of 14.3%. Eight of our patients (14.3%) where heterozygous carriers for FII G20210A mutation. The MTHFR C677T mutation was observed in 43 patients (28 heterozygous and 15 homozygous carriers) which gives the frequencies of 40.0% and 21.4%, respectively. We found increased frequency of thrombophilic mutations in a group of women with recurrent pregnancy loss. Our results suggest that maternal thrombophilia should be part of routine testing for all women after their first miscarriage.




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