PP140. 4G/5G POLYMORPHISM IN THE PROMOTER REGION OF THE PAI-1 GENE IN PATIENTS WITH MYOCARDIAL INFARCTION IN BULGARIA - A PILOT CASE-CONTROL STUDY
NOSSIKOFF A., Vikentieva E., Savov A., Dimitrov S., Bjanov K., Kremensky I., Baleva M., Denchev S. Medical University - Sofia Department of Cardiology Laboratory of Immunology, Centre of Allergy and Asthma Laboratory of Molecular Pathology e-mail: alexanderbul@yahoo.com
*Corresponding Author:
page: 110

Abstract

Aims. We performed a pilot case-control study in order to reveal the possible association between 4G allelic variant and 4G/4G genotype with myocardial infarction previously reported in the world literature in Bulgarian population.

Methods. A total of 54 patients with myocardial infarction and 85 matched healthy controls were genotyped for 4G/5G polymorphism in the PAI-1 gene promoter region. The statistical analysis was performed by χ2 test.

Results. In our study we found a trend for higher frequency of the 4G allele (p=0.34) and 4G/4G genotype (p=0.24) in patients with myocardial infarction. We conclude that 4G/4G genotype might be a transmissible risk factor for coronary thrombosis and myocardial infarction in Bulgarian population. Our study has an important limitation of a small study group. Larger studies are needed in order to confirm this promising although preliminary results.

 

Table. Relative allelic and genotype frequencies of the 4G/5G polymorphism.

 

 

4G/4G

4G/5G

5G/5G

4G

5G

Healthy controls

0,18

0,49

0,33

0,42

0,58

Patients with MI

0,26

0,44

0,30

0,48

0,52




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