PP139. eNOS AND MMP-9 GENE POLYMORPHISMS ASSOCIATION WITH CORONARY ARTERY DISEASE IN TURKISH POPULATION
E. SEVDA MENEVSE 1, Ebru Alp1, Murat Tulmac2, Derya Kan3, Atiye Cengel2, Rıdvan Yalcın2 1. Gazi University, Faculty of Medicine, Department of Medical Biology and Genetics, 06510, Besevler, Ankara; 2. Gazi University, Faculty of Medicine, Department of Cardiology, 06510, Besevler, Ankara; 3. Gazi University, Faculty of Medicine, Department of Medical Genetics, 06510, Besevler, Ankara e-mail: ebrualmaz@gazi.edu.tr
*Corresponding Author:
page: 110

Abstract

Coronary artery disease (CAD), leading to death mostly in developed countries, is a complex genetic disorder. There is a relationship between coronary artery disease and candidate genes. Among them, matrix metalloproteinase (MMP-9) and endothelial nitric oxide syntase (eNOS) are the most studied genes. It is suggested that MMP9 -1562 C/T polymorphism might affect both gene transcription and  product. The other  candidate gene region is nitric oxide syntase that associated with pathogenesis of atherosclerosis.  The eNOS T-786C polymorphism is essential for transcription regulation. The aim of this study is to determine the gene frequency of MMP9 -1562 C/T and eNOS T-786C polymorphisms in coronary artery disease in Turkish population. 71 patients and 78 healthy subjects were enrolled in our study. DNA was isolated from whole blood sample and genotyping was performed PCR-RFLP method. In this study, CC, CT and TT genotype frequency of  MMP-9 1562 C/T polymorphisms was  70.4 %, 28.2 %, 1.4% in CAD patients and 73,1 %, 23,1 %, 3,8 % in control groups, respectively. In addition, TT, TC and CC genotype frequency of  eNOS T-786C polymorphisms was  47.9 %, 50.7 %, 1.4 % in CAD patients and 61.5 %, 25.6 %, 12.8 % in control groups, respectively.  




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