PP138. LACK OF ASSOCIACIATION BETWEEN FACTOR V LEIDEN MUTATION AND 20210 G/A MUTATION OF THE PROTHROMBIN GENE AND MYOCARDIAL INFARCTION IN BULGARIAN POPULATION
NOSSIKOFF A., Vikentieva E., Savov A., Dimitrov S., Kremensky I., Baleva M., Denchev S. Department of Cardiology, University Hospital Alexandrovska Laboratory of Clinical Immunology, University Hospital Alexandrovska Laboratory of Molecular Pathology, Medical University Sofia e-mail: alexanderbul@yahoo.com
*Corresponding Author:
page: 109

Abstract

A total of 50 cases and 35 controls were genotyped using RFLP for the Factor V Leiden mutation and 20210 G/A prothrombin gene mutation. There were no statistically significant differences between the group of healthy controls and the group of cases with myocardial infarction. The genotypic and allelic frequencies for  20210 G/A mutation are higher (but not statistically significant) for  the controls than previously reported in the literature for Bulgarian population. The genotypic and allelic frequencies for Factor V mutation both in the control and patient group are lower than previously reported in the literature for the Bulgarian population. These may be a result of the relatively small count of individuals that participated at this study. Larger studies are needed to confirm the results of our pilot study.

 

 

Factor V

Patients with MI 50 (100%)

Healthy controls 35 (100%)

Allelic frequency

3(3%)

1(1,43%)

 

c2=0.44, p=0.5

Genotype frequency (heterozygous genotype)

3(6%)

1(2.86%)

 

c2=0.45, p=0.5

 

 

20210 G/A

Patients with MI 50(100%)

Healthy controls 35 (100%)

Allelic frequency

2(2%)

4(5.71%)

 

c2=1.67, p=0.20

Genotype frequency (heterozygous genotype)

2(4%)

4(11.43%)

 

c2=1.73, p=0.18

 




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