PP128. THE INVESTIGATION OF TLR2 GENE POLYMOPHISM IN ACNE PATIENTS
EBRU ETEM1, Ibrahim Kökcam2, Sevinay Oguz2, Halit Elyas1, Arzu Etem3. 1Firat University, Medical Faculty, Department of Medical Biology and Genetic, Elazıg, TURKEY; 2Firat University, Medical Faculty, Department of Dermatology, Elazıg, TURKEY;3 Okmeydani Training Hospital, Department of Biochemistry, Istanbul, TURKEY.
*Corresponding Author:
page: 105

Abstract

Acne, a chronic inflammatory disease of the pilosebaceous units of the face, neck, chest, and back, is the most common skin disorder occurring universally. Gene polymorphisms contributing to the regulation of inflammatory processes might play a role in the pathogenesis of acne. The toll-like receptor (TLR) family play a central role in the initiation of cellular innate immune responses. P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2. Our purpose investigated  the possible contribution of the TLR2 gene resulting in the amino acid changes Arg753Gln polymorphism to susceptibility in acne patients. Genomic DNA of patients was used for PCR, and the alleles were detected by Restriction Fragment Length Polymorphism (RFLP) method. For association studies, P values were calculated by the X2 method or Fisher’s exact test as No statistically significant differences were observed when the Arg753Gln genotypes and allele distribution in acne patients and healthy controls were compared. We observed a very low frequency of the Arg753Gln polymorphism in our study and control population. This study was used to analyze for the first time the influence of TLR2 gene polymorphism on the predisposition and clinical characteristics of acne patients




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