PP127. LACK OF ASSOCIATION BETWEEN PSEUDOEXFOLIATION SYNDROME AND MANGANESE SUPEROXIDE DISMUTASE POLYMORPHISM
HUSEYIN YUCE1, I. Fevzi Hepsen2, Ibrahim Tekedereli1, Ugur Can Keskin2, Halit Elyas1, Omer Akyol3 1. Firat University Medical Faculty, Department of Medical Biology and Genetics, Elazig, Turkey 2. Fatih University Medical Faculty, Department of Ophthalmology, Ankara, Turkey 3. Hacettepe University Medical Faculty, Department of Biochemistry, Ankara, Turkey email: hyuce@firat.edu.tr
*Corresponding Author:
page: 105

Abstract

Background: The aim of this clinical study was to investigate the possible association between Mn-SOD enzyme polymorphism in the mitochondrial targeting sequence and pseudoexfoliation syndrome (PEX). Methods: Ala (GTT) or Val (GCT) polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with restriction enzyme NgoM IV. Results: The frequencies of Ala-9 and Val-9 variants of Mn-SOD were similar in the controls (0.395 and 0.605) and PEX patients (0.365 and 0.635). Distributions of the genotype frequencies were also similar between the groups. The predicted values were within the 95% confidence interval of the observed genotypes. Conclusion: These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with PEX.




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