PP117. ANALYSIS OF MTHFR, ENOS AND TPA GENES POLYMORPHISMS IN WOMEN WITH PREECLAMPSIA FROM RUSSIA
I. ZAINULLIN1,2, V. Kulavsky2, A. Zainullina1, E. Khusnutdinova1 1. Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences 2. Bashkir State Medical University e-mail: club_hf@mail.ru
*Corresponding Author:
page: 101

Abstract

Preeclampsia (PE) is a hypertensive disorder specific to pregnancy and is a major cause of maternal and neonatal death and morbidity worldwide. The methylenetetrahydrofolate reductase (MTHFR), endothelial nitric oxide synthase (eNOS) and tissue plasminogen activator (TPA) genes may also play a role in the pathogenesis of PE. These loci are located on different chromosomes and encode products involved into various metabolic pathways leading to PE. The specific genes involved may depend, at least in part, on the characteristics of the population being studied (ethnicity, severity of the disease, maternal age, or gestational age at onset). We studied the eNOS VNTR polymorphism in 4 intron, TPA Alu repeat I/D polymorphism in 8 intron and MTHFR C677T polymorphism in women with PE from Bashkortostan (Russia). DNA from 132 preeclamptic pregnant women and 172 healthy control pregnant women were genotyped for polymorphisms using PCR tech nique and subsequent enzyme digestion. The frequency distributions of the genotypes of these three polymorphic marker loci of genes were similar in the case and control groups. We found no differences in the prevalence of genetic risk factors with PE compared with controls. These polymorphisms are unlikely to be risk factors for PE in our sample.




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