PP111. POLYMORPHISM OF CANDIDATES CARDIOVASCULAR DISEASES GENES IN TATARS WITH AGE GRADATION
V.V. DANILOVA, I.A. Tuktarova , A.Kh. Asilguzhina, O.E. Mustafina Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia, danivera@mail.ru e-mail: danivera@mail.ru
*Corresponding Author:
page: 98

Abstract

The aim of the present study was to investigate the molecular-genetic basis of lifespan in Tatars from Bashkortostan. The analysis of genotypes and allele frequency distribution of angiotensin-converting enzyme gene (ACE, I/D), apolipoprotein E gene (APOE, Cys112 → Arg, Arg158 → Cys) and paraoxonase gene (PON1, Q192R) polymorphisms in connection with age gradation, using PCR and PCR-RFLP methods was performed. We have examined 1116 persons, which were differentiated on separate groups according to age gradation: the young group (n=163, 1-20 years), maturity (n=239, 21-55 years), elderly (n=356, 56-74 years), senile (n=253, 75-89 years) and long-livers (n=105, 90-108 years). It was established that in senile group, in comparison with maturity group, genotype ACE*I/*D frequency was lower (P=0.008) and genotype ACE*I/*I frequency was higher (P=0.04). In senile and elderly groups, in comparison with young group, genotype PON1*Q/*Q frequency was higher (P=0.02). Genotype PON1*R/*R frequency in senile group was lower than in young group (P=0.04). Group of long-livers tended to have 2.5 times higher genotype PON1*R/*R frequency than the senile group (P=0.01). Concerning APOE gene, we have not revealed statistically significant differences in comparison groups. Thus, the changes in polymorphic markers of ACE and PON1 genotypes frequencies in various age groups in Tatars (Bashkortostan) are traced: among senile the number of ACE*I/*D and PON1*R/*R genotype carriers are reduced in comparison with persons of younger age. Besides, we found the increase of genotype PON1*R/*R and allele PON1*R frequency in long-livers.




Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006