PP108. POLYMORPHISMS OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE AND THE INTERLEUKIN-1Β GENE IN PATIENTS WITH CHRONIC RHINOSINUSITIS FROM BASHKORTOSTAN
E. SHARIPOVA1,2, L. Aznabaeva1, N. Arefyeva1, A. Zainullina2, E. Khusnutdinova2 1. Department of otorhinolaringology, Bashkir State Medical University 2. Department of Human Genomics, Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences e-mail: peppy14@rambler.ru
*Corresponding Author:
page: 96

Abstract

Text: The interleukin-1beta (IL1β) gene and the interleukin-1 receptor antagonist (IL1RN) gene are suggested to play a role in the development of rhinosinusitis. Rhinosinusitis is one of the most off-recurring illnesses in otorhinolaringology. We studied the IL1RN VNTR polymorphism in 2 introne, IL1β -511C>T polymorphism in promoter and IL1β 3953C>T polymorphism in 5 exon in patients with chronic rhinosinusitis (CRS). DNA from 62 patients with CRS (diagnosed as having ICD-10 (1994) and 82 control subjects from Bashkortostan (Russia) were genotyped using PCR and subsequent enzyme digestion. A significant differences were observed in IL1β 3953C>T polymorphism genotype (chi2 = 5.30; p = 0.039) and allele (chi2 = 5.11; p = 0.047) frequencies between patients and control subjects. The IL1B *C/*C genotype was more frequent in the patients compared with controls (chi2 = 4.29; p = 0.039; df = 1; OR = 2.16; CI 95% 1.04 - 4.52). Allelic and genotypic frequencies of IL1RN VNTR polymorphism (chi2 = 2.09; p = 0.617; chi2 = 4.69; p = 0.461 respectively) and IL1β -511C>T polymorphism (chi2 = 0.04; p = 0.892; chi2 = 0.52; p = 0.799 respectively) did not differ between patients and control subjects. These polymorphisms are unlikely to be risk factors for CRS in our sample.




Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006