PP106. ASSOCIATION OF CYTOKINE GENES POLYMORPHISMS WITH ESSENTIAL HYPERTENSION IN TATARS FROM RUSSIA
Y.R. TIMASHEVA1, T.R. Nasibullin1, A.N. Zakirova2, O.E. Mustafina1 1. Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Science 2. Bashkir State Medical University e-mail: ianina_t@yahoo.com
*Corresponding Author:
page: 95

Abstract

Extensive searches have been performed to determine candidate genes for essential hypertension (EH). It has been shown that patients with EH had an altered profile of pro- and anti-inflammatory cytokines. The aim of the present study was to determine an association of interleukin-6, interleukin-12 and interleukin-10 gene polymorphism with EH in Tatars from Bashkortostan, Russia. The study comprised 355 hypertensive patients and 173 unrelated healthy subjects from Tatar ethnic group (Bashkortostan, Russia). DNA isolated from whole venous blood using phenol-chloroform extraction was amplified in polymerase chain reaction. IL-6 -572 G/C, IL-12 1159 C/A and IL-10 -627 C/A genotypes were resolved by electrophoresis in agarose gel after digestion by restriction enzymes. We have found that IL-10 -627 *C/*C genotype and *C allele were associated with decreased risk of EH (OR=0.45, P=0.005, CI: 0.26-0.78 and OR=0.47, P=0.002, CI: 0.29-0.75, respectively). IL-6 genotypes and allele distribution did not significantly differ in patients and control group, but IL-6 -572 *G/*G genotype frequency was found to be significantly higher among those patients who had stroke, comparing to hypertensive patients without complications of EH (P=0.036) and with normotensive control subjects (P=0.028). Carriers of IL-12 1159 *A/*A genotype had lower risk of EH (OR=0.51, P=0.006, CI: 0.32-0.82) Our results suggest a role for cytokine genes in the pathogenesis of cardiovascular disease.



Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006